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- Title
Effect of the walnut polyphenol fraction on oxidative stress in type 2 diabetes mice.
- Authors
Fukuda, Toshiyuki; Ito, Hideyuki; Yoshida, Takashi
- Abstract
We examined the in vivo antioxidative effect of a polyphenol-rich walnut extract on oxidative stress in mice with type 2 diabetes. C57BL/KsJ-db/db mice were used as an accelerated oxidative animal model. The oral administration of the walnut polyphenol fraction at 200~mg/kg body weight for 4 weeks caused a significant decrease in the level of urinary 8-hydroxy-2'-deoxyguanosin, which is an in vivo marker of oxidative stress. These results imply that walnut polyphenols have both in vitro and in vivo antioxidant effects.
- Subjects
ENGLISH walnut; POLYPHENOLS; OXIDATIVE stress; MICE; TYPE 2 diabetes; WALNUT
- Publication
Biofactors, 2004, Vol 21, Issue 1-4, p251
- ISSN
0951-6433
- Publication type
Article
- DOI
10.1002/biof.552210148