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- Title
Multimodal Characterization of Vestibular Schwannoma with Magnetic Resonance Imaging and L-11C-Methionine Positron Emission Tomography.
- Authors
Burns, Megan M. J.; Sossi, Vesna; Madler, Burkhard; MacKay, Alex; Dinelle, Katie; Jivan, Salma; Ruth, Tom J.; Ma, Roy; Shaffer, Richard; McKenzie, Michael; Nichol, Alan; Martin, Montgomery; Reinsberg, Stefan
- Abstract
Purpose: A pilot study was designed to test the utility of functional magnetic resonance imaging (MRI) and L-11C-Methionine PET (MET-PET) imaging techniques as predictors of vestibular schwannoma response to radiotherapy. Methods: Patients selected for radiotherapy with previously diagnosed vestibular schwannoma were scanned within eight weeks prior to receiving radiotherapy. Patients were scanned using diffusion tensor imaging (DTI) and dynamic contrast-enhanced MRI (DCE-MRI). MET-PET scans were acquired dynamically for 60 minutes. Results: Population means for mean diffusivity and fractional anisotropy of tumours, excluding visibly cystic tumour regions (n = 12) were 1.43*10^-3 mm^2/s and 0.526, respectively. Mean Ktrans, ve, and IAUC60 for tumour population (n=12) using individually-derived arterial input functions and a 2-parameter pharmaco-kinetic model were 0.132/min, 0.144, and 8.75 Mm*s, respectively. Different tumour regions were observed to enhance under MET-PET and post-contrast T1-weighted MRI. All tumours showed enhancement under MET-PET as compared to contra-lateral region. Conclusions: DTI, DCE-MRI, and MET-PET show promise as investigatory tools for characterizing vestibular schwannoma and evaluating response to treatment. Quantitative parameters derived from DTI and DCE-MRI may aid in understanding the pathological progression of vestibular schwannoma by serving as surrogate markers of functional tissue properties. MET-PET appears to be sensitive to the metabolic activity of vestibular schwannoma.
- Subjects
ACOUSTIC neuroma; MAGNETIC resonance imaging; METHIONINE; POSITRON emission tomography; RADIOTHERAPY; TUMORS
- Publication
UBC Medical Journal, 2011, Vol 2, Issue 2, p28
- ISSN
1920-7425
- Publication type
Abstract