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- Title
THE IMPORTANCE OF ASSESSING POSITIVE LYMPH NODES FOR A PRECISE PROGNOSTIC OF COLORECTAL CANCER.
- Authors
Balint, Ionel; Andercou, Octavian; Stancu, Bogdan; Andrei, Maria; Coman, Horaţiu; Dan, Georgian; Andercou, Aurel
- Abstract
Introduction. The cancerous invasion of regional lymph nodes is one of the most important prognosis factors in colorectal cancer. For a better prognosis, the lymph node metastasization can be correlated with the degree of tumour differentiation and the presence of vascular invasion. Method. The study was conducted on 206 patients with colorectal cancer admitted and operated on between1995-2009 in two surgical units: the 2nd Surgical Clinic of Cluj Napoca and the surgical department of the Blaj Municipal Hospital. The rate of resected and neoplasm invaded lymph nodes was determined by studying the operative protocols and histopathological bulletins. Results. The patients with node positive CCR totalled 220, from whom 2640 lymph nodes were harvested. No lymph node metastases were detected in 32.17% of the patients; in 31.70% of the patients neoplasm invasion was found in 1-3 lymph nodes (pN1) and in 41.08% of the patients neoplasm invasion was found in more than 4 lymph nodes (pN2). The lymph node invasion rate (LNR), assessed by the ratio of resected to metastatic nodes, was small for the pN1 stage (0.08-0.20) and increased for the pN2 patients (0.30-0.80). The patients with low LNR showed significantly better survival rates than the patients with increased LNR. Conclusions. The invasion of regional lymph nodes is one of the most important prognosis factors in CCR. LNR is a more valuable prognosis factor than the determination of the number of metastatic lymph nodes in the evaluation of longterm evolution of the operated on colorectal cancer.
- Subjects
CLUJ-Napoca (Romania); ROMANIA; CANCER patients; CANCER prognosis; SURGICAL clinics
- Publication
Clujul Medical, 2011, Vol 84, Issue 2, p278
- ISSN
1222-2119
- Publication type
Article