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- Title
Identification of two novel hepatitis C virus subtype 2 from Tunisia (2v and 2w).
- Authors
Rajhi, Mouna; Haddad-Boubaker, Sondes; Chouikha, Anissa; Bourquain, Daniel; Michel, Janine; Hammami, Walid; Sadraoui, Amel; Touzi, Hinda; Ghedira, Kais; Triki, Henda
- Abstract
Background: Hepatitis C virus (HCV) has a high genetic diversity. Eight genotypes and 90 subtypes are currently described. Genotypes are clinically significant for therapeutic management and their determination is necessary for epidemiological studies. Methods: Tunisian patients plasma samples (n = 6) with unassigned HCV-2 subtype using partial sequencing in the NS5B and Core/E1 regions were analyzed by realizing whole-genome sequencing analysis. Phylogenetic analyses were performed to assign subtypes. Results: Phylogenetic analysis of the full genome sequences of Tunisian strains shows two subtypes within HCV-2. These later were genetically distinct from all previously established HCV-2 subtypes with nucleotide divergence greater than 15% (20% -31%). These two subtypes are proposed as new subtypes 2v and 2w. Conclusions: The discovery of two new HCV-2 subtypes circulating in the Tunisian population confirms the great diversity of HCV-2 viruses and increases the total number of HCV-2 subtypes from 21 to 23.
- Subjects
TUNISIA; HEPATITIS C virus; VIRUS diversity; SEQUENCE analysis
- Publication
PLoS ONE, 2021, Vol 16, Issue 3, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0248249