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- Title
Gastrointestinal Bleeding During Direct Oral Anticoagulant Therapy in Patients With Nonvalvular Atrial Fibrillation and Risk of Polypharmacy.
- Authors
Honda, Taku; Abe, Koichiro; Oda, Minoru; Harada, Fumito; Maruyama, Kyohei; Aoyagi, Hitoshi; Miura, Ryo; Konno, Kumiko; Arizumi, Toshihiko; Asaoka, Yoshinari; Kodashima, Shinya; Kozuma, Ken; Yamamoto, Takatsugu; Tanaka, Atsushi
- Abstract
Although concomitant medications have been raised as a factor affecting hemorrhage during direct oral anticoagulant (DOAC) therapy, details remain unelucidated. This study was conducted to clarify the relationship between concomitant medications with possible pharmacokinetic interactions and number of concomitant medications, and bleeding and embolism in patients with nonvalvular atrial fibrillation on DOACs. The subjects were 1010 patients prescribed DOACs from a single‐center at the Teikyo University Hospital between April 2011 and June 2018. This study was an exploratory analysis and investigated their course between the first prescription and December 2018, including the presence or absence of clinically relevant bleeding, gastrointestinal bleeding, and major cardiovascular and cerebrovascular events. Impacts of medications were evaluated by the general linear model with inverse probability‐weighted propensity score. The observation period was 2272 patient‐years. The rate of bleeding was 4.7%/year, gastrointestinal bleeding was 2.8%/year, and major cardiovascular and cerebrovascular events were 2.0%/year. Taking 10 or more oral medications concurrently was a significant risk for gastrointestinal bleeding (hazard ratio, 2.046 [95%CI, 1.188‐3.526]; P =.010). Nonsteroidal anti‐inflammatory drugs were the only significant risk for gastrointestinal bleeding. Clinicians should be aware of gastrointestinal bleeding when using DOACs with patients taking more than 10 medications and/or nonsteroidal anti‐inflammatory drugs.
- Subjects
EMBOLISM risk factors; RESEARCH; ACADEMIC medical centers; CONFIDENCE intervals; GASTROINTESTINAL hemorrhage; ORAL drug administration; POLYPHARMACY; NONSTEROIDAL anti-inflammatory agents; ANTICOAGULANTS; ATRIAL fibrillation; RISK assessment; TREATMENT effectiveness; DESCRIPTIVE statistics; DRUG side effects; DISEASE risk factors
- Publication
Journal of Clinical Pharmacology, 2022, Vol 62, Issue 12, p1548
- ISSN
0091-2700
- Publication type
Article
- DOI
10.1002/jcph.2106