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- Title
Optic Neuritis Associated or Not with TNF Antagonists in Patients with Inflammatory Bowel Disease.
- Authors
Alexandre, Benjamin; Vandermeeren, Yves; Dewit, Olivier; Moreels, Tom; de Boer, Nanne; Dhar, Anjan; Ziady, Chris; Shitrit, Ariella Bar-Gil; Steinwurz, Flavio; Jojic, Njegica; Costantino, Giuseppe; Bihin, Benoit; Rahier, Jean-François; Katsanos, Konstantinos H.
- Abstract
Background and Aims: Acute optic neuritis [ON] is an inflammatory condition affecting the optic nerve. Clinicians should suspect optic neuritis in cases of painful and rapidly progressive loss of central visual field. This condition may be associated with a multitude of diseases, and mostly with multiple sclerosis [MS] where it may present as an initial symptom. The literature reports that optic neuritis and MS occur in patients with inflammatory bowel disease [IBD] before and after the era of anti-tumour necrosis factor-α [TNFα] drugs. At the present moment, there is little consensus for managing this complication, currently treated with corticosteroids and discontinuation of the causative agents. Methods: We collected cases through a retrospective multicentre European Crohn's and Colitis Organisation CONFER [COllaborative Network For Exceptionally Rare case reports] project. We also performed a comprehensive retrospective search of the available literature on this topic. Results: We report herein 12 new cases of ON, including 10 under anti-TNF therapy, collected through the CONFER project. We also compare characteristics of ON associated or not with anti-TNFα agents. Conclusions: The exceptional and current observation of distant family history of MS in 17% of our patients who developed ON, despite the small number and the lack of a control arm, might be an important signal that should be taken into account in our therapeutic strategies in the future.
- Publication
Journal of Crohn's & Colitis, 2016, Vol 10, Issue 5, p541
- ISSN
1873-9946
- Publication type
Article
- DOI
10.1093/ecco-jcc/jjw003