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- Title
Mitochondrial regulation during male germ cell development.
- Authors
Wang, Xiaoli; Yin, Lisha; Wen, Yujiao; Yuan, Shuiqiao
- Abstract
Mitochondria tailor their morphology to execute their specialized functions in different cell types and/or different environments. During spermatogenesis, mitochondria undergo continuous morphological and distributional changes with germ cell development. Deficiencies in these processes lead to mitochondrial dysfunction and abnormal spermatogenesis, thereby causing male infertility. In recent years, mitochondria have attracted considerable attention because of their unique role in the regulation of piRNA biogenesis in male germ cells. In this review, we describe the varied characters of mitochondria and focus on key mitochondrial factors that play pivotal roles in the regulation of spermatogenesis, from primordial germ cells to spermatozoa, especially concerning metabolic shift, stemness and reprogramming, mitochondrial transformation and rearrangement, and mitochondrial defects in human sperm. Further, we discuss the molecular mechanisms underlying these processes.
- Publication
Cellular & Molecular Life Sciences, 2022, Vol 79, Issue 2, p1
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-022-04134-3