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- Title
The role of Helicobacter infection on atherosclerosis in diabetic patients.
- Authors
Boyuk, Banu; Avci, Rukiye Nurdan; Akin, Seydahmet; Erman, Hande; Koroglu, Emine; Keskin, Ozcan
- Abstract
Background : In this study, the aim was to investigate the effect of Helicobacter pylori (Hp) presence on carotid intima-media thickness, which is an early sign of atherosclerosis in type 2 diabetic patients. Methods: This study is a retrospective study conducted with type 2 diabetic patients who were followed up in the gastroenterology and diabetes outpatient clinic. The relationship between the presence of Hp and laboratory findings, demographic and clinical characteristics, intima-media thickness and pathology findings were analyzed in patients who underwent endoscopy for dyspepsia. Results: A total of 73 cases meeting the inclusion criteria, 32 males (43.8%) and 41 females (56.2%), between 42 and 83 years with an average age of 59 ± 10 years were included in the study. Of the cases, 31 (42.4%) were found to be Hp positive. Among the participants, the presence of carotid plaque was observed in 17 (40.5%) of the Hp negative patients and 16 (51.6%) of the Hp positive patients (p = 0.476). The presence of Hp increases the left carotid intima-media thickness (CIMT) by 0.092 mm (p = 0.018) at 95% significance level on the left. In addition, age has an effect on the increase of left CIMT (β = 0.007, p < 0.001) and right CIMT (β = 0.009, p < 0.001). LDL-C levels have an effect on right CIMT (β = 0.001, p = 0.003). Conclusion: We demonstrated that the presence of Hp increases the carotid intima-media thickness in patients with type 2 diabetes. In addition, LDL-C and age have an increasing effect on intima-media thickness.
- Subjects
STATISTICAL significance; CAROTID intima-media thickness; ENDOSCOPIC surgery; AGE distribution; RETROSPECTIVE studies; REGRESSION analysis; MANN Whitney U Test; FISHER exact test; TYPE 2 diabetes; ATHEROSCLEROSIS; T-test (Statistics); CHI-squared test; DESCRIPTIVE statistics; SOCIODEMOGRAPHIC factors; DATA analysis software; HELICOBACTER diseases; ENDOSCOPY; INDIGESTION; GASTROSCOPY; OUTPATIENT services in hospitals
- Publication
International Journal of Diabetes in Developing Countries, 2023, Vol 43, Issue 5, p687
- ISSN
0973-3930
- Publication type
Article
- DOI
10.1007/s13410-022-01145-5