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- Title
Effects of the water-holding capability of polyvinyl formal sponges on osteogenic ability in in vivo experiments.
- Authors
Togami, Wakana; Sei, Akira; Okada, Tatsuya; Taniwaki, Takuya; Fujimoto, Toru; Tahata, Shogo; Nagamura, Kazuma; Nakanishi, Yoshitaka; Mizuta, Hiroshi
- Abstract
In this study, dextran-coated polyvinyl formal (PVF) sponges with high water-holding capability were developed to increase the osteogenic response in the PVF sponge. The study aimed to estimate the effect of the increased water-holding capability of the sponges on osteogenic capacity at a bone defect site in the rabbit femur epiphysis. Bone formation was evaluated using radiography, microcomputed tomography (CT), and histological analysis at 2, 4, and 6 weeks after implantation. As shown by radiography and micro-CT findings, the dextran-coated PVF sponge without water-holding capability showed little bone formation at all evaluated time points. However, the dextran-coated PVF sponge with high water-holding capability showed increasing bone formation around the implant at 4 and 6 weeks after implantation. Furthermore, as shown by micro-CT quantitative analysis, the grafted PVF sponge with high water-holding capability showed significantly greater values for percentage of bone volume per total volume and mean bone mineral density compared with the grafted PVF sponge without water-holding capability at 4 and 6 weeks after implantation. These results suggest that the dextran-coated PVF sponge with high water-holding capability promoted osteogenesis in vivo. The PVF sponge might be a new biomaterial to be used as a fill material for bone defects. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 188-194, 2015.
- Publication
Journal of Biomedical Materials Research, Part B: Applied Biomaterials, 2015, Vol 103, Issue 1, p188
- ISSN
1552-4973
- Publication type
Article
- DOI
10.1002/jbm.b.33200