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- Title
A New Parameter Predicting Chronic Total Occlusion of Coronary Arteries: Platelet Distribution Width.
- Authors
Vatankulu, Mehmet Akif; Sonmez, Osman; Ertas, Gokhan; Bacaksiz, Ahmet; Turfan, Murat; Erdogan, Ercan; Tasal, Abdurrahman; Kul, Seref; Uyarel, Huseyin; Goktekin, Omer
- Abstract
Platelet distribution width (PDW) measures the variability in platelet size and is a marker of platelet activation. We investigated whether PDW is associated with the extent of coronary artery disease (CAD) and coronary total occlusions (CTOs). We studied 162 patients: 108 had a coronary lesion with a diameter stenosis of ≥50%, the CAD(+) group, and 54 patients had normal coronary anatomy, the CAD(−) group. The CAD(+) group was subdivided into CAD(+) CTO(+) and CAD(+) CTO(−) groups. Among patients with CAD, the CTO(+) group had a significantly greater PDW (%) than the CTO(−) group (16.9 ± 2.8, 15.4 ± 3.0, and 15.4 ± 1.9, respectively; P = .008). In a receiver–operating characteristic analysis, a PDW cut point of 15.7% was identified in patients with CTO(+) (area under curve = 0.64, 95% confidence interval 0.54-0.75). A PDW value of more than 15.7% demonstrated a sensitivity of 64% and a specificity of 66%. The PDW is a simple platelet index that may predict the presence of CTO.
- Subjects
ANALYSIS of variance; ARTERIAL occlusions; BLOOD platelets; CHI-squared test; CONFIDENCE intervals; CORONARY disease; STATISTICAL correlation; STATISTICAL hypothesis testing; STATISTICS; T-test (Statistics); U-statistics; LOGISTIC regression analysis; SEVERITY of illness index; RECEIVER operating characteristic curves; DATA analysis software; CELL size; DESCRIPTIVE statistics; PLATELET function tests
- Publication
Angiology, 2014, Vol 65, Issue 1, p60
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/0003319713486339