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- Title
Presence of Diastolic Dysfunction in Patients With Peripheral Artery Disease.
- Authors
Yamasaki, Saeko; Izawa, Atsushi; Shiba, Yuji; Tomita, Takeshi; Miyashita, Yusuke; Koyama, Jun; Ikeda, Uichi
- Abstract
Peripheral artery disease (PAD) and heart failure (HF) share many risk factors; however, the prevalence and characteristics of HF in patients with PAD have not been fully examined. We investigated 120 consecutive patients with PAD, defined by an ankle-brachial index ≤0.9. In all, 36 (30%) patients had brain natriuretic peptide (BNP) levels ≥100 pg/mL (high BNP group), and 84 (70%) patients had BNP levels <100 pg/mL (low BNP group). Univariate analysis showed that high BNP was associated with age, estimated glomerular filtration rate, hypertension, and transmitral E-wave/early diastolic mitral annular velocity (E/e′) ratio. Multivariate logistic regression analysis established that a high BNP was strongly and independently associated with the highest quartile of E/e′, highlighting these patients’ diastolic dysfunction. The prevalence of high BNP levels in patients with PAD suggests that routine BNP measurements might be useful to detect HF.
- Subjects
JAPAN; HEART failure risk factors; ACADEMIC medical centers; AGE distribution; CONFIDENCE intervals; ECHOCARDIOGRAPHY; EPIDEMIOLOGY; GLOMERULAR filtration rate; PEPTIDE hormones; PERIPHERAL vascular diseases; STATISTICS; U-statistics; LOGISTIC regression analysis; DATA analysis; RETROSPECTIVE studies; ANKLE brachial index; DATA analysis software; DESCRIPTIVE statistics
- Publication
Angiology, 2013, Vol 64, Issue 7, p540
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/0003319713476135