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- Title
Serum anti-müllerian hormone levels in healthy females: a nomogram ranging from infancy to adulthood.
- Authors
Lie Fong S; Visser JA; Welt CK; de Rijke YB; Eijkemans MJ; Broekmans FJ; Roes EM; Peters WH; Hokken-Koelega AC; Fauser BC; Themmen AP; de Jong FH; Schipper I; Laven JS; Lie Fong, S; Visser, J A; Welt, C K; de Rijke, Y B; Eijkemans, M J C; Broekmans, F J
- Abstract
<bold>Context: </bold>Anti-müllerian hormone (AMH) is an accurate marker of ovarian reserve. However, sufficiently large sets of normative data from infancy to the end of reproductive life are scarce.<bold>Objective: </bold>This study was an assessment of serum AMH levels in healthy females.<bold>Subjects: </bold>In 804 healthy females ranging from infancy until the end of the reproductive period, serum AMH levels were measured with an enzyme-linked immunometric assay. All adults had regular menstrual cycles. The majority was proven fertile and none of them had used oral contraceptive pills prior to study inclusion.<bold>Results: </bold>In the total cohort, AMH was inversely correlated with age (r = -0.24; P < 0.001). The age at which the maximum AMH value was attained was at 15.8 yr. In girls younger than 15.8 yr, serum AMH and age were positively correlated (r = +0.18; P = 0.007). Thereafter AMH levels remained stable (r = -0.33; P = 0.66), whereas from the age of 25.0 yr onward, an inverse correlation between AMH and age (r = -0.47; P < 0.001) was observed. At any given age, considerable interindividual differences in serum AMH levels were observed.<bold>Conclusion: </bold>During infancy AMH levels increase, whereas during adolescence, a plateau until the age of 25 yr was observed. From the age of 25 yr onward, serum AMH levels correlate inversely with age, implying that AMH is applicable as a marker of ovarian reserve only in women of 25 yr old and older. Our nomogram may facilitate counseling women on their reproductive potential.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2012, Vol 97, Issue 12, p4650
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2012-1440