We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
SPLUNC1 Loses Its Antimicrobial Activity in Acidic Cystic Fibrosis Airway Secretions.
- Authors
Ahmad, Saira; Gilmore, Rodney C.; Alexis, Neil E.; Tarran, Robert
- Abstract
The article discusses Cystic fibrosis (CF) is a genetic disease caused by dysfunctional CF transmembrane conductance regulator anion secretion that leading to airway dehydration. Topics include the antimicrobial compound SPLUNC1 has found in airway secretions and targets gram-negative bacteria; and acidic CF ASL negatively affecting SPLUNC1 function.
- Subjects
ANTIBIOTICS; ANTI-infective agents; BACTERIAL diseases; COMPARATIVE studies; CYSTIC fibrosis; GLYCOPROTEINS; RESEARCH methodology; MEDICAL cooperation; PHOSPHOPROTEINS; RESEARCH; SECRETION; EVALUATION research; DISEASE complications; PHARMACODYNAMICS
- Publication
American Journal of Respiratory & Critical Care Medicine, 2019, Vol 200, Issue 5, p633
- ISSN
1073-449X
- Publication type
letter
- DOI
10.1164/rccm.201812-2303LE