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- Title
Nickel‐Catalyzed Coupling of Arylzinc Halides with Thioesters.
- Authors
Gehrtz, Paul H.; Kathe, Prasad; Fleischer, Ivana
- Abstract
Abstract: The Pd‐catalyzed Fukuyama reaction of thioesters with organozinc reagents is a mild, functional‐group‐tolerant method for acylation chemistry. Its Ni‐catalyzed variant might be a sustainable alternative to expensive catalytic Pd sources. We investigated the reaction of S‐ethyl thioesters with aryl zinc halides with hetero‐ and homotopic Ni precatalysts and several ligands. The results show that both homo‐ and heterotopic species may contribute to catalysis. The substrate scope using an operationally homogeneous defined Ni complex was established. Acyl radicals are postulated as short‐lived intermediates.
- Subjects
NICKEL catalysts; ARYL halides; THIOESTERS; COUPLING reactions (Chemistry); ZINC halides; DICHLOROMETHANE; CARBOXYLIC acids
- Publication
Chemistry - A European Journal, 2018, Vol 24, Issue 35, p8774
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201801887