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- Title
Citrate‐Based Tannin‐Bridged Bone Composites for Lumbar Fusion.
- Authors
Guo, Jinshan; Tian, Xinggui; Xie, Denghui; Rahn, Kevin; Gerhard, Ethan; Kuzma, Michelle Laurel; Zhou, Dongfang; Dong, Cheng; Bai, Xiaochun; Lu, Zhihui; Yang, Jian
- Abstract
Conventional bone composites consistently fail to mimic the chemical composition and integrated organic/inorganic structure of natural bone, lacking sufficient mechanics as well as inherent osteoconductivity and osteoinductivity. Through a facile surface coating process, the strong adhesive, tannic acid (TA), is adhered to the surface of the natural bone component, hydroxyapatite (HA), with and without the immobilization of in situ formed silver nanoparticles. Residual functional groups available on the immobilized TA substituents are subsequently covalently linked to the citrate‐based biodegradable polymer, poly(octamethylene citrate) (POC), effectively bridging the organic and inorganic phases. Due to the synergistic effects of the tannin and citrate components, the obtained citrate‐based tannin‐bridged bone composites (CTBCs) exhibit vastly improved compression strengths up to 323.0 ± 21.3 MPa compared to 229.9 ± 15.6 MPa for POC‐HA, and possess tunable degradation profiles, enhanced biomineralization performance, favorable biocompatibility, increased cell adhesion and proliferation, as well as considerable antimicrobial activity. In vivo study of porous CTBCs using a lumbar fusion model further confirms CTBCs' osteoconductivity and osteoinductivity, promoting bone regeneration. CTBCs possess great potential for bone regeneration applications while the immobilized TA additionally preserves surface bioconjugation sites to further tailor the bioactivity of CTBCs.
- Subjects
BONES; CITRATES; HYDROXYAPATITE; COATING processes; BONE regeneration; TANNINS; SILVER nanoparticles
- Publication
Advanced Functional Materials, 2020, Vol 30, Issue 27, p1
- ISSN
1616-301X
- Publication type
Article
- DOI
10.1002/adfm.202002438