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- Title
Downregulation of EphA2 expression suppresses the growth and metastasis in squamous-cell carcinoma of the head and neck in vitro and in vivo.
- Authors
Liu, Yong; Yu, Changyun; Qiu, Yuanzheng; Huang, Donghai; Zhou, Xiaojuan; Zhang, Xin; Tian, Yongquan
- Abstract
Purpose: Our previous study has revealed that EphA2 overexpression is significantly associated with aggressive behavior and poor prognosis in patients with squamous-cell carcinoma of the head and neck (SCCHN). However, the function of EphA2 in tumorigenesis and cervical lymph node metastasis of SCCHN has never been elucidated in vivo. Methods: EphA2 was knocked down in SCCHN cell lines. CCK-8 assays, fluorescence-activated cell sorting analysis, invasion and migration assays were performed in vitro. In vivo tumorigenicity assays were performed, and the impact on cervical lymph node metastasis was evaluated. Results: The present investigation demonstrated that suppression of EphA2 resulted in a significant inhibition of proliferation, migration, invasion of SCCHN cells in vitro and markedly diminished their tumorigenicity and lymph node metastasis in vivo. Conclusions: These results suggest that EphA2 plays a critical role in SCCHN growth and metastasis and may be a promising therapeutic target to prevent the progression of SCCHN.
- Subjects
SQUAMOUS cell carcinoma; METASTASIS; HEAD &; neck cancer; CANCER prognosis; CARCINOGENESIS
- Publication
Journal of Cancer Research & Clinical Oncology, 2012, Vol 138, Issue 2, p195
- ISSN
0171-5216
- Publication type
Article
- DOI
10.1007/s00432-011-1087-9