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- Title
Characterization of the Sideritis scardica Extract SidTea+ TM and Its Effect on Physiological Profile, Metabolic Health and Redox Biomarkers in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study.
- Authors
Papanikolaou, Konstantinos; Kouloridas, Konstantinos; Rosvoglou, Anastasia; Gatsas, Athanasios; Georgakouli, Kalliopi; Deli, Chariklia K.; Draganidis, Dimitrios; Argyropoulou, Aikaterini; Michailidis, Dimitris; Fatouros, Ioannis G.; Jamurtas, Athanasios Z.
- Abstract
This study aimed to characterize a Sideritis scardica extract (SidTea+TM) and investigate its effect on the physiological profile, metabolic health and redox status in healthy individuals. The chemical profile and antioxidant potential of the SidTea+TM extract were evaluated by UPLC-HRMS analysis and in vitro cell-free methods. Twenty-eight healthy adults participated in this randomized, double-blind, placebo-controlled study. Participants consumed 1500 mg/day of SidTea+TM or a placebo for 4 weeks. At baseline and post-supplementation, participants were assessed for their anthropometric and physiological profile and provided a resting blood sample. SidTea+TM decreased (p < 0.05) systolic blood pressure (−10.8 mmHg), mean arterial pressure (−4.5 mmHg), resting heart rate (−3.1 bpm) and handgrip strength of the non-dominant limb (−0.8 kg) whereas the placebo decreased (p < 0.05) handgrip strength of the dominant (−5.8 kg) and non-dominant (−3.2 kg) limb. SidTea+TM also resulted in an increase (p < 0.05) in estimated VO2max (+1.1 mL/kg/min) and a reduction (p < 0.05) in γ-GT and SGPT enzymatic activity in serum (−3.7 and −3.3 U/L, respectively). Finally, SidTea+TM increased (p < 0.001) total antioxidant capacity and decreased (p < 0.05) lipid peroxidation levels in plasma. These results indicate that SidTea+TM is a potent and safe to use antioxidant that can elicit positive changes in indices of blood pressure, cardiorespiratory capacity, liver metabolism, and redox status in healthy adults over a 4-week supplementation period.
- Subjects
OXIDANT status; SYSTOLIC blood pressure; BLOOD pressure; OXIDATION-reduction reaction; ADULTS; HEART beat; BIOMARKERS
- Publication
Molecules, 2024, Vol 29, Issue 5, p1113
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules29051113