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- Title
Irbesartan Attenuates Atherosclerosis in Watanabe Heritable Hyperlipidemic Rabbits: Noninvasive Imaging of Inflammation by <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography.
- Authors
Yan Zhao; Keita Fukao; Songji Zhao; Ayahisa Watanabe; Tadateru Hamada; Kazuaki Yamasaki; Yoichi Shimizu; Naoki Kubo; Naoyuki Ukon; Toru Nakano; Nagara Tamaki; Yuji Kuge
- Abstract
The purpose of this study was to assess the usefulness of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in evaluating the antiatherogenic effects of irbesartan, an angiotensin II type 1 receptor blocker. Watanabe heritable hyperlipidemic rabbits were divided into the irbesartan-treated group (75 mg/kg/d; n = 14) and the control group (n = 14). After a 9-month treatment, rabbits underwent 18F-FDG PET. Using the aortic lesions, autoradiography and histologic examinations were performed. PET imaging clearly visualized the thoracic lesions of control rabbits and showed a significant decrease in the 18F-FDG uptake level of irbesartan-treated rabbits (78.8% of controls; p < .05). Irbesartan treatment significantly reduced the plaque size (43.1% of controls) and intraplaque macrophage infiltration level (48.1% of controls). The 18F-FDG uptake level in plaques positively correlated with the plaque size (r = .65, p < .05) and macrophage infiltration level (r = .57, p < .05). Noninvasive imaging by 18F-FDG PET is useful for evaluating the therapeutic effects of irbesartan and reflects inflammation, a key factor involved in the therapeutic effects.
- Subjects
ATHEROSCLEROSIS treatment; IRBESARTAN; HERITABILITY; HYPERLIPIDEMIA treatment; LABORATORY rabbits
- Publication
Molecular Imaging, 2015, Vol 14, p1
- ISSN
1535-3508
- Publication type
Article
- DOI
10.2310/7290.2015.00004