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- Title
Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor.
- Authors
Patel, Onisha; Pellicci, Daniel G; Gras, Stephanie; Sandoval-Romero, Maria L; Uldrich, Adam P; Mallevaey, Thierry; Clarke, Andrew J; Le Nours, Jérôme; Theodossis, Alex; Cardell, Susanna L; Gapin, Laurent; Godfrey, Dale I; Rossjohn, Jamie
- Abstract
Natural killer T cells (NKT cells) are divided into type I and type II subsets on the basis of differences in their T cell antigen receptor (TCR) repertoire and CD1d-antigen specificity. Although the mode by which type I NKT cell TCRs recognize CD1d-antigen has been established, how type II NKT cell TCRs engage CD1d-antigen is unknown. Here we provide a basis for how a type II NKT cell TCR, XV19, recognized CD1d-sulfatide. The XV19 TCR bound orthogonally above the A? pocket of CD1d, in contrast to the parallel docking of type I NKT cell TCRs over the F? pocket of CD1d. At the XV19 TCR-CD1d-sulfatide interface, the TCR? and TCR? chains sat centrally on CD1d, where the malleable CDR3 loops dominated interactions with CD1d-sulfatide. Accordingly, we highlight the diverse mechanisms by which NKT cell TCRs can bind CD1d and account for the distinct antigen specificity of type II NKT cells.
- Subjects
CD1 antigen; KILLER cells; ANTIGEN receptors; SULFATIDES; T cell receptors; IMMUNE recognition; IMMUNOLOGY
- Publication
Nature Immunology, 2012, Vol 13, Issue 9, p857
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni.2372