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- Title
Penetrability of intravenous biapenem into the peritoneal fluid of laparotomy patients and the peritoneal pharmacodynamics against gram-negative bacteria.
- Authors
Ikawa K; Morikawa N; Ikeda K; Sakashita M; Ohge H; Sueda T
- Abstract
This study examined the penetrability of biapenem into the peritoneal fluid (PF) of laparotomy patients and assessed the peritoneal pharmacodynamics against common gramnegative bacteria that cause intra-abdominal infections. Biapenem (300 mg) was administered by 0.5-h infusion to 10 patients before the laparotomy. The drug concentrations in both plasma and PF were determined, analyzed pharmacokinetically, and used for a stochastic simulation with the minimum inhibitory concentration (MIC) distribution data against clinical isolates. Intravenous biapenem penetrated well into PF, with an area under the drug concentration-time curve PF/plasma ratio of 0.77 ± 0.11 (mean ± SD, n = 10). The probabilities of attaining the pharmacodynamic target (30% of the time above MIC) in PF were >/= 90% against Escherichia coli, Klebsiella species, Enterobacter cloacae, and Proteus mirabilis with 300 mg every 8 h (0.5-h infusion). However, 600 mg every 12 h (4-h infusion) or 600 mg every 8 h (0.5-h infusion) was required to achieve a target-attainment probability of >/= 90% against Pseudomonas aeruginosa. These results should provide better understanding of the peritoneal pharmacokinetics of biapenem, while also helping to choose the appropriate dosage for intra-abdominal infections on the basis of the pharmacodynamic assessment.
- Publication
Journal of Applied Research, 2009, Vol 9, Issue 3, p107
- ISSN
1537-064X
- Publication type
Journal Article