We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Genetic liability to ADHD and substance use disorders in individuals with ADHD.
- Authors
Wimberley, Theresa; Agerbo, Esben; Horsdal, Henriette Thisted; Ottosen, Cæcilie; Brikell, Isabell; Als, Thomas Damm; Demontis, Ditte; Børglum, Anders D.; Nordentoft, Merete; Mors, Ole; Werge, Thomas; Hougaard, David; Bybjerg‐Grauholm, Jonas; Hansen, Marie Bækvad; Mortensen, Preben Bo; Thapar, Anita; Riglin, Lucy; Langley, Kate; Dalsgaard, Søren
- Abstract
Aims: 1) To investigate whether genetic liability to attention‐deficit/hyperactivity disorder (ADHD), indexed by polygenic risk scores for ADHD (PRS‐ADHD), is associated with substance use disorders (SUD) in individuals with ADHD. 2) To investigate whether other individual‐ or family‐related risk factors for SUD could mediate or confound this association. Design Population‐based cohort study Setting and participants: ADHD cases in the iPSYCH sample (a Danish case‐cohort sample of genotyped cases with specific mental disorders), born in Denmark between 1981 and 2003 (N = 13 116). Register‐based information on hospital diagnoses of SUD was available until December 31, 2016. Measurements We estimated odds ratios (ORs) with 95% confidence intervals (CIs) for any SUD as well as for different SUD types (alcohol, cannabis, and other illicit drugs) and severities (use, abuse, and addiction), with effect sizes corresponding to a comparison of the highest PRS‐ADHD decile to the lowest. Findings PRS‐ADHD were associated with any SUD (OR = 1.30, 95% CI: 1.11–1.51). Estimates were similar across different types and severity levels of SUD. Other risk factors for SUD (male sex, age at ADHD diagnosis, comorbid conduct problems, and parental factors including SUD, mental disorders, and socio‐economic status) were independently associated with increased risk of SUD. PRS‐ADHD explained a minor proportion of the variance in SUD (0.2% on the liability scale) compared to the other risk factors. The association between PRS‐ADHD and any SUD was slightly attenuated (OR = 1.21, 95% CI: 1.03–1.41) after adjusting for the other risk factors for SUD. Furthermore, associations were nominally higher in females than in males (ORfemales = 1.59, 95% CI: 1.19–2.12, ORmales = 1.18, 95% CI: 0.98–1.42). Conclusions: A higher genetic liability to attention‐deficit/hyperactivity disorder appears to be associated with higher risks of substance use disorders in individuals with attention‐deficit/hyperactivity disorder.
- Subjects
ATTENTION-deficit hyperactivity disorder; CANNABIS (Genus); COMPARATIVE studies; CONFIDENCE intervals; GENETICS; LONGITUDINAL method; MENTAL illness; RISK assessment; SUBSTANCE abuse; COMORBIDITY; SOCIOECONOMIC factors; EFFECT sizes (Statistics); SEVERITY of illness index; FAMILY history (Medicine); DESCRIPTIVE statistics; ODDS ratio
- Publication
Addiction, 2020, Vol 115, Issue 7, p1368
- ISSN
0965-2140
- Publication type
Article
- DOI
10.1111/add.14910