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- Title
Biomarkers in age‐related macular degeneration.
- Authors
Balaratnasingam, Chandrakumar; Curcio, Christine A.
- Abstract
This article discusses the use of biomarkers in age-related macular degeneration (AMD), specifically geographic atrophy (GA). GA is a leading cause of severe vision loss in non-neovascular AMD, and there is currently no effective treatment for it. Optical coherence tomography (OCT) is a valuable tool for identifying biomarkers and assessing complications of AMD. The article highlights the work of the Consensus Definition for Atrophy Associated with Age-Related Macular Degeneration on OCT (CAM) group, which has defined the features of GA and developed criteria for its diagnosis. The article also discusses the importance of biomarkers in personalized medicine and their potential to reduce the burden of care and improve vision outcomes in AMD. A recent study examined two OCT biomarkers, nascent GA and large choroidal hypertransmission, and found that they were both associated with the development of GA. The article concludes by emphasizing the need for further research on biomarkers and therapeutic strategies to prevent vision loss in AMD.
- Subjects
MACULAR degeneration; BIOMARKERS; POLYPOIDAL choroidal vasculopathy; RETINAL imaging
- Publication
Clinical & Experimental Ophthalmology, 2024, Vol 52, Issue 4, p384
- ISSN
1442-6404
- Publication type
Article
- DOI
10.1111/ceo.14404