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- Title
Biomarkers of cellular aging during a controlled human malaria infection.
- Authors
Miglar, Aurelie; Reuling, Isaie J.; Yap, Xi Zen; Färnert, Anna; Sauerwein, Robert W.; Asghar, Muhammad
- Abstract
Cellular aging is difficult to study in individuals with natural infection, given the diversity of symptom duration and clinical presentation, and the high interference of aging-related processes with host and environmental factors. To address this challenge, we took advantage of the controlled human malaria infection (CHMI) model. This approach allowed us to characterize the relationship among cellular aging markers prior, during and post malaria pathophysiology in humans, controlling for infection dose, individual heterogeneity, previous exposure and co-infections. We demonstrate that already low levels of Plasmodium falciparum impact cellular aging by inducing high levels of inflammation and redox-imbalance; and that cellular senescence reversed after treatment and parasite clearance. This study provides insights into the complex relationship of telomere length, cellular senescence, telomerase expression and aging-related processes during a single malaria infection.
- Subjects
CELLULAR aging; MALARIA; TELOMERES; BIOMARKERS; INFECTION; MIXED infections; PLASMODIUM falciparum
- Publication
Scientific Reports, 2021, Vol 11, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-021-97985-y