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- Title
Editorial: Cancer Ecosystems.
- Authors
Martinez-Outschoorn, Ubaldo E.; Bartrons, Mireia; Bartrons, Ramon
- Abstract
Highlights from the article: Compared to differentiated cells, many tumor cells have an altered energy metabolism. Most studies on the metabolism of cancer cells have focused on the investigation of a single type of intra-tumoral cell, although recent studies have described a more complex scene, where the tumor ecosystem via metabolic symbiosis plays a critical role in cancer progression ([9], [10], [29]). This transport through TNTs between malignant and stromal cells can modify the gene regulation and metabolism of TME cells, playing a critical role in tumor growth and metastasis, as well as in resistance to different treatments. Metabolic synergy between cancer and stroma cells is a driver of cancer aggressiveness and it has been shown that lactate is an essential metabolic intermediate between TME cells, fueling the oxidative metabolism of oxygenated tumor cells.
- Subjects
EXTRACELLULAR matrix proteins; ECOSYSTEMS; B cells; THYMIC stromal lymphopoietin; ECOLOGICAL disturbances; CANCER
- Publication
Frontiers in Oncology, 2019, p1
- ISSN
2234-943X
- Publication type
Editorial
- DOI
10.3389/fonc.2019.00718