We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Heterogeneity in lung macrophage control of Mycobacterium tuberculosis is modulated by T cells.
- Authors
Lai, Rocky; Williams, Travis; Rakib, Tasfia; Lee, Jinhee; Behar, Samuel M.
- Abstract
Following Mycobacterium tuberculosis infection, alveolar macrophages are initially infected but ineffectively restrict bacterial replication. The distribution of M. tuberculosis among different cell types in the lung changes with the onset of T cell immunity when the dominant infected cellular niche shifts from alveolar to monocyte-derived macrophages (MDM). We hypothesize that changes in bacterial distribution among different cell types is driven by differences in T cell recognition of infected cells and their subsequent activation of antimicrobial effector mechanisms. We show that CD4 and CD8 T cells efficiently eliminate M. tuberculosis infection in alveolar macrophages, but they have less impact on suppressing infection in MDM, which may be a bacterial niche. Importantly, CD4 T cell responses enhance MDM recruitment to the lung. Thus, the outcome of infection depends on the interaction between the T cell subset and the infected cell; both contribute to the resolution and persistence of the infection. Both T cells and lung macrophages are involved in the control of lung tuberculosis infection. Here the authors examine the dependence of the lung macrophage response upon the presence of T cells and show that CD4 and CD8 T cells promote the elimination of M.Tb in alveolar macrophages but have less impact on monocyte-derived macrophages.
- Subjects
MYCOBACTERIUM tuberculosis; T cells; CELLULAR recognition; ALVEOLAR macrophages; LUNGS; MACROPHAGES; T cell receptors; IMMUNOSENESCENCE
- Publication
Nature Communications, 2024, Vol 15, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-024-48515-7