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An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 4, p. 1835, doi. 10.1172/JCI73441
By:
- Bonsignori, Mattia;
- Wiehe, Kevin;
- Grimm, Sebastian K.;
- Lynch, Rebecca;
- Guang Yang;
- Kozink, Daniel M.;
- Perrin, Florence;
- Cooper, Abby J.;
- Kwan-Ki Hwang;
- Xi Chen;
- Mengfei Liu;
- McKee, Krisha;
- Parks, Robert J.;
- Eudailey, Joshua;
- Minyue Wang;
- Clowse, Megan;
- Criscione-Schreiber, Lisa G.;
- Moody, M. Anthony;
- Ackerman, Margaret E.;
- Boyd, Scott D.
Publication type:
Article
HIV-1 Vaccine-elicited Antibodies Reverted to Their Inferred Naive Germline Reveal Associations between Binding Affinity and in vivo Activation.
Published in:
Scientific Reports, 2016, p. 20987, doi. 10.1038/srep20987
By:
- Dai, Kaifan;
- Khan, Salar N;
- Wang, Yimeng;
- He, Linling;
- Guenaga, Javier;
- Ingale, Jidnyasa;
- Sundling, Christopher;
- O'Dell, Sijy;
- McKee, Krisha;
- Phad, Ganesh;
- Corcoran, Martin;
- Wilson, Richard;
- Mascola, John R;
- Zhu, Jiang;
- Li, Yuxing;
- Hedestam, Gunilla B Karlsson;
- Wyatt, Richard T
Publication type:
Article
Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-42098-5
By:
- Banach, Bailey B.;
- Pletnev, Sergei;
- Olia, Adam S.;
- Xu, Kai;
- Zhang, Baoshan;
- Rawi, Reda;
- Bylund, Tatsiana;
- Doria-Rose, Nicole A.;
- Nguyen, Thuy Duong;
- Fahad, Ahmed S.;
- Lee, Myungjin;
- Lin, Bob C.;
- Liu, Tracy;
- Louder, Mark K.;
- Madan, Bharat;
- McKee, Krisha;
- O'Dell, Sijy;
- Sastry, Mallika;
- Schön, Arne;
- Bui, Natalie
Publication type:
Article
Trispecific antibody targeting HIV-1 and T cells activates and eliminates latently-infected cells in HIV/SHIV infections.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39265-z
By:
- Promsote, Wanwisa;
- Xu, Ling;
- Hataye, Jason;
- Fabozzi, Giulia;
- March, Kylie;
- Almasri, Cassandra G.;
- DeMouth, Megan E.;
- Lovelace, Sarah E.;
- Talana, Chloe Adrienna;
- Doria-Rose, Nicole A.;
- McKee, Krisha;
- Hait, Sabrina Helmold;
- Casazza, Joseph P.;
- Ambrozak, David;
- Beninga, Jochen;
- Rao, Ercole;
- Furtmann, Norbert;
- Birkenfeld, Joerg;
- McCarthy, Elizabeth;
- Todd, John-Paul
Publication type:
Article
Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-018-07851-1
By:
- Lai, Yen-Ting;
- Wang, Tao;
- O'Dell, Sijy;
- Louder, Mark K.;
- Schön, Arne;
- Cheung, Crystal S. F.;
- Chuang, Gwo-Yu;
- Druz, Aliaksandr;
- Lin, Bob;
- McKee, Krisha;
- Peng, Dongjun;
- Yang, Yongping;
- Zhang, Baoshan;
- Herschhorn, Alon;
- Sodroski, Joseph;
- Bailer, Robert T.;
- Doria-Rose, Nicole A.;
- Mascola, John R.;
- Langley, David R.;
- Kwong, Peter D.
Publication type:
Article
Ultrapotent Broadly Neutralizing Human‐llama Bispecific Antibodies against HIV‐1.
Published in:
Advanced Science, 2024, v. 11, n. 26, p. 1, doi. 10.1002/advs.202309268
By:
- Xu, Jianliang;
- Zhou, Tongqing;
- McKee, Krisha;
- Zhang, Baoshan;
- Liu, Cuiping;
- Nazzari, Alexandra F.;
- Pegu, Amarendra;
- Shen, Chen‐Hsiang;
- Becker, Jordan E.;
- Bender, Michael F.;
- Chan, Payton;
- Changela, Anita;
- Chaudhary, Ridhi;
- Chen, Xuejun;
- Einav, Tal;
- Kwon, Young Do;
- Lin, Bob C.;
- Louder, Mark K.;
- Merriam, Jonah S.;
- Morano, Nicholas C.
Publication type:
Article
Potent and broad HIV-neutralizing antibodies in memory B cells and plasma.
Published in:
Science Immunology, 2017, v. 2, n. 7, p. 1, doi. 10.1126/sciimmunol.aal2200
By:
- Williams, LaTonya D.;
- Ofek, Gilad;
- Schätzle, Sebastian;
- McDaniel, Jonathan R.;
- Xiaozhi Lu;
- Nicely, Nathan I.;
- Liming Wu;
- Lougheed, Caleb S.;
- Bradley, Todd;
- Louder, Mark K.;
- McKee, Krisha;
- Bailer, Robert T.;
- O'Dell, Sijy;
- Georgiev, Ivelin S.;
- Seaman, Michael S.;
- Parks, Robert J.;
- Marshall, Dawn J.;
- Anasti, Kara;
- Guang Yang;
- Xiaoyan Nie
Publication type:
Article
Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Published in:
Science Translational Medicine, 2017, v. 9, n. 381, p. 1, doi. 10.1126/scitranslmed.aai7514
By:
- Bonsignori, Mattia;
- Kreider, Edward F.;
- Fera, Daniela;
- Meyerhoff, R. Ryan;
- Bradley, Todd;
- Wiehe, Kevin;
- Alam, S. Munir;
- Aussedat, Baptiste;
- Walkowicz, William E.;
- Kwan-Ki Hwang;
- Saunders, Kevin O.;
- Ruijun Zhang;
- Gladden, Morgan A.;
- Monroe, Anthony;
- Kumar, Amit;
- Shi-Mao Xia;
- Cooper, Melissa;
- Louder, Mark K.;
- McKee, Krisha;
- Bailer, Robert T.
Publication type:
Article
Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site.
Published in:
PLoS Pathogens, 2015, v. 11, n. 5, p. 1, doi. 10.1371/journal.ppat.1004932
By:
- Crooks, Ema T.;
- Tong, Tommy;
- Chakrabarti, Bimal;
- Narayan, Kristin;
- Georgiev, Ivelin S.;
- Menis, Sergey;
- Huang, Xiaoxing;
- Kulp, Daniel;
- Osawa, Keiko;
- Muranaka, Janelle;
- Stewart-Jones, Guillaume;
- Destefano, Joanne;
- O’Dell, Sijy;
- LaBranche, Celia;
- Robinson, James E.;
- Montefiori, David C.;
- McKee, Krisha;
- Du, Sean X.;
- Doria-Rose, Nicole;
- Kwong, Peter D.
Publication type:
Article
HIV-1 Receptor Binding Site-Directed Antibodies Using a VH1-2 Gene Segment Orthologue Are Activated by Env Trimer Immunization.
Published in:
PLoS Pathogens, 2014, v. 10, n. 8, p. 1, doi. 10.1371/journal.ppat.1004337
By:
- Navis, Marjon;
- Tran, Karen;
- Bale, Shridhar;
- Phad, Ganesh E.;
- Guenaga, Javier;
- Wilson, Richard;
- Soldemo, Martina;
- McKee, Krisha;
- Sundling, Christopher;
- Mascola, John;
- Li, Yuxing;
- Wyatt, Richard T.;
- Karlsson Hedestam, Gunilla B.
Publication type:
Article
Preclinical Development of a Fusion Peptide Conjugate as an HIV Vaccine Immunogen.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-59711-y
By:
- Ou, Li;
- Kong, Wing-Pui;
- Chuang, Gwo-Yu;
- Ghosh, Mridul;
- Gulla, Krishana;
- O’Dell, Sijy;
- Varriale, Joseph;
- Barefoot, Nathan;
- Changela, Anita;
- Chao, Cara W.;
- Cheng, Cheng;
- Druz, Aliaksandr;
- Kong, Rui;
- McKee, Krisha;
- Rawi, Reda;
- Sarfo, Edward K.;
- Schön, Arne;
- Shaddeau, Andrew;
- Tsybovsky, Yaroslav;
- Verardi, Raffaello
Publication type:
Article
Structures of HIV-1 Neutralizing Antibody 10E8 Delineate the Mechanistic Basis of Its Multi-Peak Behavior on Size-Exclusion Chromatography.
Published in:
Antibodies (2073-4468), 2021, v. 10, n. 2, p. 23, doi. 10.3390/antib10020023
By:
- Do Kwon, Young;
- Wang, Xiangchun E.;
- Bender, Michael F.;
- Yang, Rong;
- Li, Yile;
- McKee, Krisha;
- Rawi, Reda;
- O'Dell, Sijy;
- Schneck, Nicole A.;
- Shaddeau, Andrew;
- Zhang, Baoshan;
- Arnold, Frank J.;
- Connors, Mark;
- Doria-Rose, Nicole A.;
- Kwong, Peter D.;
- Lei, Q. Paula
Publication type:
Article
Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor.
Published in:
Science Translational Medicine, 2014, v. 6, n. 243, p. 1, doi. 10.1126/scitranslmed.3008992
By:
- Pegu, Amarendra;
- Zhi-yong Yang;
- Boyington, Jeffrey C.;
- Lan Wu;
- Sung-Youl Ko;
- Schmidt, Stephen D.;
- McKee, Krisha;
- Wing-Pui Kong;
- Wei Shi;
- Xuejun Chen;
- Todd, John-Paul;
- Letvin, Norman L.;
- Jinghe Huang;
- Nason, Martha C.;
- Hoxie, James A.;
- Kwong, Peter D.;
- Connors, Mark;
- Rao, Srinivas S.;
- Mascola, John R.;
- Nabel, Gary J.
Publication type:
Article
Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8.
Published in:
PLoS ONE, 2016, v. 11, n. 6, p. 1, doi. 10.1371/journal.pone.0157409
By:
- Soto, Cinque;
- Ofek, Gilad;
- Joyce, M. Gordon;
- Zhang, Baoshan;
- McKee, Krisha;
- Longo, Nancy S.;
- Yang, Yongping;
- Huang, Jinghe;
- Parks, Robert;
- Eudailey, Joshua;
- Lloyd, Krissey E.;
- Alam, S. Munir;
- Haynes, Barton F.;
- null, null;
- Mullikin, James C.;
- Connors, Mark;
- Mascola, John R.;
- Shapiro, Lawrence;
- Kwong, Peter D.
Publication type:
Article
Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting.
Published in:
PLoS Pathogens, 2017, v. 13, n. 1, p. 1, doi. 10.1371/journal.ppat.1006148
By:
- Doria-Rose, Nicole A.;
- Altae-Tran, Han R.;
- Roark, Ryan S.;
- Schmidt, Stephen D.;
- Sutton, Matthew S.;
- Louder, Mark K.;
- Chuang, Gwo-Yu;
- Bailer, Robert T.;
- Cortez, Valerie;
- Kong, Rui;
- McKee, Krisha;
- O’Dell, Sijy;
- Wang, Felicia;
- Abdool Karim, Salim S.;
- Binley, James M.;
- Connors, Mark;
- Haynes, Barton F.;
- Martin, Malcolm A.;
- Montefiori, David C.;
- Morris, Lynn
Publication type:
Article
Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03335-4
By:
- Steinhardt, James J.;
- Guenaga, Javier;
- Turner, Hannah L.;
- McKee, Krisha;
- Louder, Mark K.;
- O’Dell, Sijy;
- Chi-I Chiang;
- Lin Lei;
- Galkin, Andrey;
- Andrianov, Alexander K.;
- Doria-Rose, Nicole A.;
- Bailer, Robert T.;
- Ward, Andrew B.;
- Mascola, John R.;
- Yuxing Li
Publication type:
Article
Human CD4-binding site antibody elicited by polyvalent DNA prime-protein boost vaccine neutralizes cross-clade tier-2-HIV strains.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-48514-8
By:
- Wang, Shixia;
- Chan, Kun-Wei;
- Wei, Danlan;
- Ma, Xiuwen;
- Liu, Shuying;
- Hu, Guangnan;
- Park, Saeyoung;
- Pan, Ruimin;
- Gu, Ying;
- Nazzari, Alexandra F.;
- Olia, Adam S.;
- Xu, Kai;
- Lin, Bob C.;
- Louder, Mark K.;
- McKee, Krisha;
- Doria-Rose, Nicole A.;
- Montefiori, David;
- Seaman, Michael S.;
- Zhou, Tongqing;
- Kwong, Peter D.
Publication type:
Article
Characterization of broadly neutralizing antibody responses to HIV-1 in a cohort of long term non-progressors.
Published in:
PLoS ONE, 2018, v. 13, n. 3, p. 1, doi. 10.1371/journal.pone.0193773
By:
- González, Nuria;
- McKee, Krisha;
- Lynch, Rebecca M.;
- Georgiev, Ivelin S.;
- Jimenez, Laura;
- Grau, Eulalia;
- Yuste, Eloísa;
- Kwong, Peter D.;
- Mascola, John R.;
- Alcamí, José
Publication type:
Article
Eliminating antibody polyreactivity through addition of N-linked glycosylation.
Published in:
Protein Science: A Publication of the Protein Society, 2015, v. 24, n. 6, p. 1019, doi. 10.1002/pro.2682
By:
- Chuang, Gwo‐Yu;
- Zhang, Baoshan;
- McKee, Krisha;
- O'Dell, Sijy;
- Kwon, Young Do;
- Zhou, Tongqing;
- Blinn, Julie;
- Lloyd, Krissey;
- Parks, Robert;
- Von Holle, Tarra;
- Ko, Sung‐Youl;
- Kong, Wing‐Pui;
- Pegu, Amarendra;
- Wang, Keyun;
- Baruah, Kavitha;
- Crispin, Max;
- Mascola, John R.;
- Moody, M. Anthony;
- Haynes, Barton F.;
- Georgiev, Ivelin S.
Publication type:
Article

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