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- Title
Does the Expression of Transforming Growth Factor ß-1.
- Authors
Wei Wang; Lei Liu; Yuan Li; Sheng-Shou Hu; Yun-Hu Song; Xin Wang
- Abstract
We investigated whether the expression of transforming growth factor ß-1 in the left atrial appendage affected the outcome of the radiofrequency modified maze procedure in patients with rheumatic valve disease and long-standing persistent atrial fibrillation. Messenger RNA and protein expression of transforming growth factor ß-1 and volume fractions of collagen types I and III were measured in 80 patients with rheumatic valve atrial fibrillation who underwent valve surgery with the radiofrequency modified maze procedure; the same was done in a control group of 20 patients with rheumatic valve disease and sinus rhythm who underwent valve surgery alone. At 6 months' follow-up, atrial fibrillation recurred in 24 of the 80 patients in the study group. The messenger RNA and protein expressions of transforming growth factor ß-1, collagen type I volume fraction, and left atrial dimension had increased gradually in the control group and in the study subgroups that maintained sinus rhythm or relapsed into atrial fibrillation (P <0.05). The messenger RNA and protein expressions of transforming growth factor ß-1 correlated positively with collagen type I volume fraction (r=0.723, P <0.001 and r=0.745, P <0.001, respectively) and left atrial dimension (r=0.762, P <0.001 and r=0.765, P <0.001, respectively). In the sinus rhythm-maintained subgroup, the patients who regained functional atrial contraction had lower messenger RNA and protein expression of transforming growth factor ß-1 than did the patients who failed to retain such function (P <0.05). We conclude that the expression of transforming growth factor ß-1 in the resected left atrial appendage affects the recurrence of atrial fibrillation and restoration of functional left atrial contraction after the radiofrequency modified maze procedure.
- Subjects
TRANSFORMING growth factors; HEART diseases; CARDIOVASCULAR diseases; ATRIAL fibrillation; RNA
- Publication
Texas Heart Institute Journal, 2012, Vol 39, Issue 1, p17
- ISSN
1526-6702
- Publication type
Article