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- Title
Association of the MTHFR 677C>T polymorphism with obesity and biochemical variables in a young population of Mexico.
- Authors
Leal-Ugarte, Evelia; Peralta-Leal, Valeria; Meza-Espinoza, Juan Pablo; Durán-González, Jorge; Macías-Gómez, Nelly; Bocanegra-Alonso, Anabel; Lara-Ramos, José Ramón
- Abstract
Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms have been associated with overweight people and obesity. The goal of this study was to investigate the relationship of the MTHFR 677C>T polymorphism with obesity and biochemical variables in young individuals of Mexico. A total of 316 young individuals were included in the study, 172 with normal weight (NW) and 144 with over weight/obesity. Body mass index (BMI) was classified as NW, overweight, and obesity. Also, waist circumference was measured. Moreover, glucose, total cholesterol, and triglycerides were determined. Genotyping for MTHFR 677C>T polymorphism was performed by the PCR-RFLP method. There was no difference in the distribution of the MTHFR 677C>T polymorphism between individuals with NW and overweight/obesity; neither when they were divided by overweight vs NW, nor when we contrasted obese vs NW. However, an analysis stratified by gender showed a significant protector effect of the TT genotype against obesity in males and elevated waist circumference in females. Also, overweight/obese individuals with TT genotype had less risk of high cholesterol or triglycerides than overweight/obese subjects with the other genotypes. These results suggest that the MTHFR 677T polymorphism might not be a risk factor for being overweight/obesity. Rather, on the basis of our results, this variant could be a protector effect. However, further large-scale population-based studies are still necessary to clarify the role of the MTHFR 677C>T polymorphism in overweight, obesity, and lipid profile level.
- Subjects
MEXICO; OBESITY; CHILDHOOD obesity; METHYLENETETRAHYDROFOLATE reductase; BODY mass index; OVERWEIGHT persons; WAIST circumference
- Publication
Journal of Medical Biochemistry, 2019, Vol 38, Issue 4, p461
- ISSN
1452-8258
- Publication type
Article
- DOI
10.2478/jomb-2018-0046