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- Title
Mycobacteria other thanMycobacterium tuberculosisare not present in erythema induratum/nodular vasculitis: a case series and literature review of the clinical and histologic findings.
- Authors
Bayer-Garner, Ilene B.; Cox, Mark D.; Scott, Margie A.; Smoller, Bruce R.
- Abstract
Erythema induratum (EI)/nodular vasculitis (NV) is characterized by recurrent crops of tender oedematous nodules on the lower legs. A lobular panniculitis with granulomatous inflammation, vasculitis, focal necrosis and septal fibrosis is present.Mycobacterium tuberculosisDNA has been detected in some lesions by means of polymerase chain reaction (PCR). Ten cases of EI/NV were found. H&E slides were reviewed. PCR assays forM. tuberculosisand mycobacteria other thanM. tuberculosis(MOTT) were performed. PCR did not revealM. tuberculosis(0%) or MOTT (0%) DNA, with positive controls, indicating the reliability of the assays. Among the MOTT, cutaneous infections are most commonly caused byM. marinum. Subcutaneous tuberculoid granulomas may be seen withM. kansasii,M. marinum,M. scrofulaceumandM. aviumcomplex.M. gordonae,M. szulgaiandM. malmoenserarely cause cutaneous infections.M. simiae,M. gastriandM. asiaticumare probably not cutaneous pathogens.M. tuberculosisand MOTT DNA was not found in EI/NV. EI/NV has diverse aetiologies with varying pathogeneses leading to similar histologic changes. The cases analysed may not have had an infectious aetiology. However, in EI/NV, performance of PCR for MOTT as well asM. tuberculosiscomplex may still be beneficial, particularly in cases from immunocompromised hosts.Bayer-Garner IB, Cox MD, Scott MA, Smoller BR. Mycobacteria other thanMycobacterium tuberculosisare not present in erythema induratum/nodular vasculitis: a case series and literature review of the clinical and histologic findings.
- Subjects
MYCOBACTERIUM tuberculosis; ERYTHEMA; VASCULITIS; INFLAMMATION; SKIN infections; POLYMERASE chain reaction; DERMATOLOGY; PATHOLOGY
- Publication
Journal of Cutaneous Pathology, 2005, Vol 32, Issue 3, p220
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/j.0303-6987.2005.00296.x