We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Insight to changing morphologic patterns of glomerulopathy in adult Pakistani patients: an institutional perspective.
- Authors
Hashmi, Atif Ali; Hussain, ZubaidaFida; Edhi, Muhammad Muzzammil; Mumtaz, Shazia; Faridi, Naveen; Khan, Mehmood
- Abstract
Background: Idiopathic nephrotic syndrome encompasses diverse histogenetic patterns and depicts socioeconomic and demographic differences attributable to genetic profile, environmental factors and prevalence of infectious diseases. A lack of renal registry in our country necessitates a need to document changing histologic patterns of nephrotic syndrome as noted in different parts of the world. Methods: We retrospectively analyzed 140 patients who underwent renal biopsy at Liaquat National Hospital from January 2009 to December 2013 over a period of 3 years. On the basis of clinical profile cases were segregated into nephritic and nephrotic syndrome and histologic and immunoflourescence findings were analyzed. Results: Among 140 cases of glomerulonephritis diagnosed in the study period, 98 cases (70%) were those of primary glomerulonephritis and 42 were of secondary glomerulopathy (30%). Membranous glomerulonephritis was the most common primary glomerulonephritis (33.6%) followed by focal segmental glomerulosclerosis FSGS (20.4%), whereas lupus nephritis is the most common secondary glomerulopathy (47.6%) followed by amyloidosis and diabetic glomerulosclerosis (16.6% each). Conclusion: We found a considerable high incidence of membranous glomerulonephritis and FSGS in our population that entails a need to investigate prevalence of associated factors like Hepatitis B and HIV infections in population at risk. Moreover, renal biopsy registry would be instrumental in this regard to record changing disease pattern in this part of the world.
- Subjects
HISTOGENESIS; NEPHROTIC syndrome; GLOMERULONEPHRITIS; AMYLOIDOSIS; LUPUS nephritis
- Publication
BMC Research Notes, 2016, Vol 9, p1
- ISSN
1756-0500
- Publication type
Article
- DOI
10.1186/s13104-016-1876-y