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- Title
Green synthesis and characterization of poly(glycerol‐azelaic acid) and its nanocomposites for applications in regenerative medicine.
- Authors
Hosseini Chenani, Fatemeh; Rezaei, Vahid Faghihi; Fakhri, Vafa; Wurm, Frederik R.; Uzun, Lokman; Goodarzi, Vahabodin
- Abstract
A series of novel bio‐polyester nanocomposites based on glycerin and azelaic acid as monomers incorporating hydroxyapatite (HA) nanoparticles were fabricated via in situ polymerization method. Chemical structure of the samples was investigated by 1H‐NMR, 13C‐NMR, and Fourier‐transform infrared spectroscopy (FTIR). Energy dispersive X‐ray‐mapping analysis illustrated that the nanoparticles were well dispersed in the poly (glycerol azelaic acid) (PGAZ) matrix. Viscoelastic properties of the samples under various frequencies were examined in which the PGAZ specimen containing 1.0 wt% of HA nanoparticles (PGAZH1.0) exhibited superlative properties. Furthermore, the alterations in the glass transition temperature of the samples were comprehensively discussed. Thermal gravimetric analysis displayed that nanocomposites generally have a difference in degradation patterns from that of the pristine sample. Dynamic contact angle demonstrated that the presence of HA nanoparticles imposed a significant influence on hydrophilicity. The hydrolytic degradation values at pH = 7 and pH = 11 were measured and determined that the degradation rate for the PGAZ sample containing 1.5 wt% HA (PGAZH1.5) was higher than those of the other samples. Moreover, in vitro studies elucidated that cell attachment on PGAZH1.0 and PAZH1.5 surfaces were acceptable.
- Subjects
REGENERATIVE medicine; GLYCERIN; NANOCOMPOSITE materials; THERMOGRAVIMETRY; GLASS transition temperature; HUMIC acid; INFRARED spectroscopy; HYDROXYAPATITE
- Publication
Journal of Applied Polymer Science, 2021, Vol 138, Issue 24, p1
- ISSN
0021-8995
- Publication type
Article
- DOI
10.1002/app.50563