We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Early onset oral tongue squamous cell carcinoma: Associated factors and patient outcomes.
- Authors
Campbell, Benjamin R.; Sanders, Courtney B.; Netterville, James L.; Sinard, Robert J.; Rohde, Sarah L.; Langerman, Alexander; Mannion, Kyle; Kim, Young J.; Lang Kuhs, Krystle A.; Murphy, Barbara A.; Warner, Jeremy L.; Lewis, James S.; Smith, Derek K.
- Abstract
Background: Incidence of oral tongue squamous cell carcinoma (OTC) is rising among those under age 50 years. The etiology is unknown. Methods: A total of 395 cases of OTC diagnosed and/or treated at Vanderbilt University Medical Center between 2000 and 2017 were identified. Of those, 113 (28.6%) were early onset (age < 50 years). Logistic regression was used to identify factors associated with early onset OTC. Cox proportional hazards models evaluated survival and recurrence. Results: Compared to typical onset patients, patients with early onset OTC were more likely to receive multimodality treatment (surgery and radiation; adjusted odds ratio [aOR], 2.7; 95% confidence interval [CI], 1.2‐6.3) and report a history of snuff use (aOR, 5.4; 95% CI, 1.8‐15.8) and were less likely to report a history of cigarette use (aOR, 0.5; 95% CI, 0.2‐0.9). Early onset patients had better overall survival (adjusted hazard ratio, 0.6). Conclusions: This is the largest study to evaluate factors associated with early onset OTC and the first to report an association with snuff.
- Subjects
VANDERBILT University. Medical Center; SQUAMOUS cell carcinoma; PROPORTIONAL hazards models; TONGUE; ACADEMIC medical centers
- Publication
Head & Neck, 2019, Vol 41, Issue 6, p1952
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.25650