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- Title
Clinical significance of epithelial-to-mesenchymal transition in laryngeal carcinoma: Its role in the different subsites.
- Authors
Mezi, Silvia; Chiappetta, Caterina; Carletti, Raffaella; Nardini, Andrea; Cortesi, Enrico; Orsi, Errico; Piesco, Gabriele; Di Gioia, Cira
- Abstract
Background During epithelial-to-mesenchymal transition, cancer cells lose adhesion capacity gaining migratory properties. The role of the process on prognosis has been evaluated in 50 cases of laryngeal carcinoma. Methods E-cadherin, N-cadherin, β-catenin, α-catenin, γ-catenin, caveolin-1, and vimentin immunohistochemical expression were evaluated using a double score based on staining intensity and cellular localization. Results Cytoplasmic E-cadherin and α/γ catenin staining were associated with a decrease in survival, cytoplasmic β-catenin was associated with advanced stage, and N-cadherin and vimentin expression were associated with poor differentiation and tumor relapse. On the basis of cancer cells, epithelial or mesenchymal morphological and immunophenotypic similarity we identified 4 main subgroups correlated with a transition to a more undifferentiated phenotype, which have a different pattern of relapse and survival. Conclusion The negative prognostic role of epithelial-to-mesenchymal transition has been confirmed and a predictive role in glottic tumors has been suggested, leading us to propose epithelial-to-mesenchymal transition as an additional adverse feature in laryngeal carcinoma.
- Subjects
LARYNGEAL cancer; EPITHELIAL cells; MESENCHYMAL stem cells; CANCER cell migration; CANCER cells
- Publication
Head & Neck, 2017, Vol 39, Issue 9, p1806
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.24838