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- Title
Optimized dose of imatinib for treatment of gastrointestinal stromal tumors: A meta-analysis.
- Authors
Liu, Shang Long; Chen, Ge; Zhao, Yu Pei; Wu, Wen Ming; Zhang, Tai Ping
- Abstract
Objective To investigate the efficacy and safety of standard-dose versus high-dose imatinib. Methods After a systematic review of English language articles, five studies including 2008 patients were eligible for the meta-analysis. Data extracted from each study were synthesized into overall odds ratios ( OR). Results The overall OR for the high dose vs standard dose was 1.19 (95% CI 1.00-1.42) and the Z-score for the overall effect was 1.93 ( P = 0.054), suggesting that high-dose imatinib added no survival benefits. The dose-related toxicity was also assessed in the same way. The rates of rash, hemorrhage, nausea, vomiting and taste disturbance increased as dose increased ( P < 0.05), whereas the incidence of headache, abdominal pain, edema, fatigue, anemia, infection, muscle cramp and constipation was nearly identical and showed no significant difference. Conclusions Imatinib at a standard dose produces a similar effect to that at a high dose. The severity of the toxicity is associated with the dose of imatinib. However, larger and randomized studies are needed to draw definitive conclusions.
- Subjects
IMATINIB; GASTROINTESTINAL stromal tumors; SYSTEMATIC reviews; META-analysis; VOMITING
- Publication
Journal of Digestive Diseases, 2013, Vol 14, Issue 1, p16
- ISSN
1751-2972
- Publication type
Article
- DOI
10.1111/1751-2980.12010