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- Title
Similar familial underpinnings for full and subsyndromal pediatric bipolar disorder: A familial risk analysis.
- Authors
Wozniak, Janet; Uchida, Mai; Faraone, Stephen V; Fitzgerald, Maura; Vaudreuil, Carrie; Carrellas, Nicholas; Davis, Jacqueline; Wolenski, Rebecca; Biederman, Joseph
- Abstract
Objectives To examine the validity of subthreshold pediatric bipolar I disorder ( BP-I), we compared the familial risk for BP-I in the child probands who had either full BP-I, subthreshold BP-I, ADHD, or were controls that neither had ADHD nor bipolar disorder. Methods BP-I probands were youth aged 6−17 years meeting criteria for BP-I, full (N=239) or subthreshold (N=43), and also included were their first-degree relatives (N=687 and N=120, respectively). Comparators were youth with ADHD (N=162), controls without ADHD or bipolar disorder (N=136), and their first-degree relatives (N=511 and N=411, respectively). We randomly selected 162 non-bipolar ADHD probands and 136 non-bipolar, non- ADHD control probands of similar age and sex distribution to the BP-I probands from our case−control ADHD family studies. Psychiatric assessments were made by trained psychometricians using the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children Epidemiological Version ( KSADS-E) and Structured Clinical Interview for DSM-IV ( SCID) structured diagnostic interviews. We analyzed rates of bipolar disorder using multinomial logistic regression. Results Rates of full BP-I significantly differed between the four groups (χ23=32.72, P<.001): relatives of full BP-I probands and relatives of subthreshold BP-I probands had significantly higher rates of full BP-I than relatives of ADHD probands and relatives of control probands. Relatives of full BP-I, subthreshold BP-I, and ADHD probands also had significantly higher rates of major depressive disorder compared to relatives of control probands. Conclusions Our results showed that youth with subthreshold BP-I had similarly elevated risk for BP-I and major depressive disorder in first-degree relatives as youth with full BP-I. These findings support the diagnostic continuity between subsyndromal and fully syndromatic states of pediatric BP-I disorder.
- Subjects
BIPOLAR disorder in children; DIAGNOSIS of schizophrenia; PATHOLOGICAL psychology; COMPARATIVE psychology; LOGISTIC regression analysis; DIAGNOSIS
- Publication
Bipolar Disorders, 2017, Vol 19, Issue 3, p168
- ISSN
1398-5647
- Publication type
Article
- DOI
10.1111/bdi.12494