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- Title
Influence of mannitol and dopamine on renal function during elective infrarenal aortic clamping in man.
- Authors
Paul, Michael D.; Mazer, David; Byrick, Robert J.; Rose, Keith; Goldstein, Marc B.; Paul, M D; Mazer, C D; Byrick, R J; Rose, D K; Goldstein, M B
- Abstract
The impact of elective infrarenal aortic clamping on parameters of renal function was evaluated in 27 extracellular fluid volume expanded patients. Significant transient decreases (p less than 0.05) in glomerular filtration rate were observed in all three groups either in the early or late post-clamp release period, despite maintenance of hemodynamic stability. This study documents transient decreases in glomerular filtration rate which occurred following release of the infrarenal aortic cross-clamp. No clinically important benefit from the use of mannitol and dopamine over extracellular fluid volume expansion with saline alone was demonstrated in the prevention of the changes in renal function associated with aortic cross-clamping.
- Subjects
ABDOMINAL aorta surgery; KIDNEY physiology; ABDOMINAL aorta; EXTRACELLULAR space; AORTIC aneurysms; BLOOD pressure; CARDIAC output; COMPARATIVE studies; CREATININE; DOPAMINE; FLUID therapy; GLOMERULAR filtration rate; KIDNEY function tests; RESEARCH methodology; MEDICAL cooperation; POTASSIUM; PULMONARY artery; RESEARCH; SURGICAL therapeutics; URINE; EVALUATION research; MANNITOL; PHYSIOLOGY; SURGERY
- Publication
American Journal of Nephrology, 1986, Vol 6, Issue 6, p427
- ISSN
0250-8095
- Publication type
journal article
- DOI
10.1159/000167248