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- Title
Estimation of p70S6K Thr<sup>389</sup> and 4E‐BP1 Thr<sup>37/46</sup> phosphorylation support dependency of tension per se in a dose‐response relationship for downstream mTORC1 signalling.
- Authors
Rindom, Emil; Kristensen, Anders M.; Overgaard, Kristian; Vissing, Kristian; Paoli, Frank Vincenzo
- Abstract
Estimation of p70S6K Thr389 and 4E-BP1 Thr37/46 phosphorylation support dependency of tension per se in a dose-response relationship for downstream mTORC1 signalling In a letter to the editor by Figueiredo et al,[1] entitled 'On the appropriateness of antibody selection to estimate mTORC1 activity', the authors question our choice of mTORC1 biomarkers.[2] We much appreciate the input and the possibility to emphasize our conclusions. Using p70S6K Thr SP 389 sp and 4E-BP1 Thr SP 37/46 sp to evaluate mTORC1 activation we have now confirmed the novel finding of Rindom et al[2] that a direct link exists between tension per se and activation of mTORC1 signalling.
- Subjects
DOSE-response relationship in biochemistry; PHOSPHORYLATION; MYOSIN; MUSCLE metabolism
- Publication
Acta Physiologica, 2020, Vol 229, Issue 1, p1
- ISSN
1748-1708
- Publication type
Article
- DOI
10.1111/apha.13426