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- Title
Emerging Insights into the Ependymoma Epigenome.
- Authors
Mack, Stephen C.; Witt, Hendrik; Wang, Xin; Milde, Till; Yao, Yuan; Bertrand, Kelsey C.; Korshunov, Andrey; Pfister, Stefan M.; Taylor, Michael D.
- Abstract
Ependymoma is the third most common pediatric brain tumor, yet because of the paucity of effective therapeutic interventions, 45% of patients remain incurable. Recent transcriptional and copy number profiling of the disease has identified few driver genes and in fact points to a balanced genomic profile. Candidate gene approaches looking at hypermethylated promoters and genome-wide epigenetic arrays suggest that DNA methylation may be critical to ependymoma pathogenesis. This review attempts to highlight existing and emerging evidence implicating the ependymoma epigenome as a key player and that epigenetic modifiers may offer new targeted therapeutic avenues for patients.
- Subjects
BRAIN tumors; DNA methylation; EPIGENESIS; PEDIATRIC research; GENOMICS
- Publication
Brain Pathology, 2013, Vol 23, Issue 2, p206
- ISSN
1015-6305
- Publication type
Article
- DOI
10.1111/bpa.12020