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- Title
Adrenergic Enhancement of Inhibitory Transmission in the Accessory Olfactory Bulb.
- Authors
Araneda, Ricardo C.; Firestein, Stuart
- Abstract
Noradrenergic modulation of dendrodendritic synapses between the mitral and granule cells in the accessory olfactory bulb (AOB) is postulated to play a key role in the formation of memory in olfactory-mediated behaviors. Current models propose that noradrenaline (NA) increases excitation of mitral/tufted cells (M/TCs) by decreasing the release of GABA from granule cells. However, surprisingly little is known about the actions ofNAat the cellular level in the AOB. Here, in recordings fromAOBslices, we show thatNAdecreases the firing frequency of M/TCs in response to stimulation. This effect is attributable to an increase in the GABA inhibitory input to M/TCs. Application of NA (10 µM) produced an ∼20-fold increase in the frequency of GABA-induced miniature IPSCs (mIPSCs) without changing their amplitude. A pharmacological analysis indicated that the increase in mIPSCs frequency results from activation of α1 adrenergic receptors. In addition to increasing the mIPSC frequency, NA also potentiatedGABAinhibitory currents induced by direct stimulation of granule cells. Together, our results suggest that NA increases the release of GABA from granule cells by acting on presynaptic receptors. Thus, the role of the noradrenergic activity in the AOB may be opposite than suggested previously: we find that the overall effect of NA in the AOB is inhibition of M/TCs.
- Subjects
NOSE; SMELL; SYNAPSES; ADRENERGIC receptors; EXCITATION (Physiology)
- Publication
Journal of Neuroscience, 2006, Vol 26, Issue 12, p3292
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.4768-05.2006