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- Title
Stress hyperglycemia as first sign of asymptomatic type 1 diabetes: an instructive case.
- Authors
Wang, Wei-De; Chu, Chun-Hao; Tien, Chiung-Hsi; Wang, Shuo-Yu; Liu, Shih-Yao; Lin, Chien-Ming
- Abstract
<bold>Background: </bold>Stress hyperglycemia (SH) is considered a transient manifestation and routine diagnostic evaluation was thought to be unnecessary due to the lack of definite correlation with diabetes mellitus (DM). Although SH was usually benign and long-term treatment was superfluous, it might be the first sign of insulinopenic status such as type 1 DM (T1DM).<bold>Case Presentation: </bold>We reported a boy with acute asthma attack presented incidentally with high blood glucose levels exceeding 300 mg/dL and obvious glycemic variability. A prolonged hyperglycemic duration of more than 48 h was also noticed. To elucidate his unique situation, glucagon test and insulin autoantibody survey were done which showed insulinopenia with positive anti-insulin antibody and glutamic acid decarboxylase antibody despite the absence of overt DM symptoms and signs.<bold>Conclusions: </bold>This case highlights that SH might be a prodromal presentation in T1DM children, especially when accompanied simultaneously with extreme hyperglycemia, apparent glucose variability, as well as prolonged hyperglycemic duration.
- Subjects
HYPERGLYCEMIA; TYPE 1 diabetes; GLUTAMATE decarboxylase; BLOOD sugar; INSULIN antibodies; RESEARCH; IMMUNOGLOBULINS; RESEARCH methodology; MEDICAL cooperation; EVALUATION research; INSULIN; COMPARATIVE studies; DISEASE complications
- Publication
BMC Pediatrics, 2021, Vol 21, Issue 1, p1
- ISSN
1471-2431
- Publication type
journal article
- DOI
10.1186/s12887-021-02811-z