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Drug Targeting and Nanomedicine: Lessons Learned from Liver Targeting and Opportunities for Drug Innovation.
Published in:
Pharmaceutics, 2022, v. 14, n. 1, p. 217, doi. 10.3390/pharmaceutics14010217
By:
- Salvati, Anna;
- Poelstra, Klaas
Publication type:
Article
Osteoprotegerin Is more than a Possible Serum Marker in Liver Fibrosis: A Study into Its Function in Human and Murine Liver.
Published in:
Pharmaceutics, 2020, v. 12, n. 5, p. 471, doi. 10.3390/pharmaceutics12050471
By:
- Adhyatmika, Adhyatmika;
- Beljaars, Leonie;
- Putri, Kurnia S. S.;
- Habibie, Habibie;
- Boorsma, Carian E.;
- Reker-Smit, Catharina;
- Luangmonkong, Theerut;
- Guney, Burak;
- Haak, Axel;
- Mangnus, Keri A.;
- Post, Eduard;
- Poelstra, Klaas;
- Ravnskjaer, Kim;
- Olinga, Peter;
- Melgert, Barbro N.
Publication type:
Article
Design of a Gene Panel to Expose the Versatile Role of Hepatic Stellate Cells in Human Liver Fibrosis.
Published in:
Pharmaceutics, 2020, v. 12, n. 3, p. 278, doi. 10.3390/pharmaceutics12030278
By:
- van Dijk, Fransien;
- Hazelhoff, Christa M.;
- Post, Eduard;
- Prins, Gerian G. H.;
- Rombouts, Krista;
- Poelstra, Klaas;
- Olinga, Peter;
- Beljaars, Leonie
Publication type:
Article
Gliotoxin non-selectively induces apoptosis in fibrotic and normal livers.
Published in:
Liver International, 2006, v. 26, n. 2, p. 232, doi. 10.1111/j.1478-3231.2005.01212.x
By:
- Hagens, Werner I.;
- Olinga, Peter;
- Meijer, Dirk K. F.;
- Groothuis, Geny M. M.;
- Beljaars, Leonie;
- Poelstra, Klaas
Publication type:
Article
Targeted Recombinant Fusion Proteins of IFNγ and Mimetic IFNγ with PDGFβR Bicyclic Peptide Inhibits Liver Fibrogenesis In Vivo.
Published in:
PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0089878
By:
- Bansal, Ruchi;
- Prakash, Jai;
- De Ruiter, Marieke;
- Poelstra, Klaas
Publication type:
Article
Enhanced Effectivity of an ALK5-Inhibitor after Cell-Specific Delivery to Hepatic Stellate Cells in Mice with Liver Injury.
Published in:
PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0056442
By:
- van Beuge, Marike Marjolijn;
- Prakash, Jai;
- Lacombe, Marie;
- Post, Eduard;
- Reker-Smit, Catharina;
- Beljaars, Leonie;
- Poelstra, Klaas
Publication type:
Article
Anticancer Effects of 15d-Prostaglandin-J2 in Wild-Type and Doxorubicin-Resistant Ovarian Cancer Cells: Novel Actions on SIRT1 and HDAC.
Published in:
PLoS ONE, 2011, v. 6, n. 9, p. 1, doi. 10.1371/journal.pone.0025192
By:
- Jong, Edwin de;
- Winkel, Peter;
- Poelstra, Klaas;
- Prakash, Jai
Publication type:
Article
Intraglomerular platelet aggregation and experimental glomerulonephritis.
Published in:
Kidney International, 1990, v. 37, n. 6, p. 1500, doi. 10.1038/ki.1990.141
By:
- Poelstra, Klaas;
- Hardonk, Machiel J.;
- Koudstaal, Jan;
- Bakker, Winston W.
Publication type:
Article
Antibody-Free Detection of Protein Tyrosine Nitration in Tissue Sections.
Published in:
ChemBioChem, 2011, v. 12, n. 13, p. 2016, doi. 10.1002/cbic.201100148
By:
- Wisastra, Rosalina;
- Poelstra, Klaas;
- Bischoff, Rainer;
- Maarsingh, Harm;
- Haisma, Hidde J.;
- Dekker, Frank J.
Publication type:
Article
Selective delivery of IFN-γ to renal interstitial myofibroblasts: a novel strategy for the treatment of renal fibrosis.
Published in:
FASEB Journal, 2015, v. 29, n. 3, p. 1029, doi. 10.1096/fj.14-258459
By:
- Poosti, Fariba;
- Bansal, Ruchi;
- Yazdani, Saleh;
- Prakash, Jai;
- Post, Eduard;
- Klok, Pieter;
- den Born, Jacob van;
- de Borst, Martin H.;
- van Goor, Harry;
- Poelstra, Klaas;
- Hillebrands, Jan-Luuk
Publication type:
Article
A role for intestinal alkaline phosphatase in the maintenance of local gut immunity.
Published in:
2011
By:
- Chen, Kathryn;
- Malo, Madhu;
- Beasley-Topliffe, Laura;
- Poelstra, Klaas;
- Millan, Jose;
- Mostafa, Golam;
- Alam, Sayeda;
- Ramasamy, Sundaram;
- Warren, H.;
- Hohmann, Elizabeth;
- Hodin, Richard;
- Chen, Kathryn T;
- Malo, Madhu S;
- Beasley-Topliffe, Laura Kline;
- Millan, Jose Luis;
- Alam, Sayeda N;
- Warren, H Shaw;
- Hohmann, Elizabeth L;
- Hodin, Richard A
Publication type:
journal article
The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing.
Published in:
FASEB Journal, 2007, v. 21, n. 9, p. 2005, doi. 10.1096/fj.06-6889com
By:
- Serriere-Lanneau, Valérie;
- Teixeira-Clerc, Fatima;
- Liying Li;
- Schippers, Marlies;
- De Wries, Willie;
- Julien, Boris;
- Tran-Van-Nhieu, Jeanne;
- Manin, Sylvie;
- Poelstra, Klaas;
- Chun, Jerold;
- Carpentier, Stéphane;
- Levade, Thierry;
- Mallat, Ariane;
- Lotersztajn, Sophie
Publication type:
Article
Necrotizing enterocolitis: a potential protective role for intestinal alkaline phosphatase as lipopolysaccharide detoxifying enzyme.
Published in:
Frontiers in Pediatrics, 2024, p. 1, doi. 10.3389/fped.2024.1401090
By:
- Dos Santos Martins, Raquel;
- Hulscher, Jan B. F.;
- Timmer, Albert;
- Kooi, Elisabeth M. W.;
- Poelstra, Klaas
Publication type:
Article
Tumor-targeted intracellular delivery of anticancer drugs through the mannose-6-phosphate/insulin-like growth factor II receptor.
Published in:
International Journal of Cancer, 2010, v. 126, n. 8, p. 1966, doi. 10.1002/ijc.24914
By:
- Prakash, Jai;
- Beljaars, Leonie;
- Harapanahalli, Akshay K.;
- Zeinstra-Smith, Mieke;
- de Jager-Krikken, Alie;
- Hessing, Martin;
- Steen, Herman;
- Poelstra, Klaas
Publication type:
Article
Targeted elimination of activated hepatic stellate cells by an anti-epidermal growth factor-receptor single chain fragment variable antibody-tumor necrosis factor-related apoptosis-inducing ligand (scFv425-sTRAIL).
Published in:
Journal of Gene Medicine, 2014, v. 16, n. 9/10, p. 281, doi. 10.1002/jgm.2776
By:
- Arabpour, Mohammad;
- Poelstra, Klaas;
- Helfrich, Wijnand;
- Bremer, Edwin;
- Haisma, Hidde J.
Publication type:
Article
A data‐driven framework for evolutionary problems in solid mechanics.
Published in:
ZAMM -- Journal of Applied Mathematics & Mechanics / Zeitschrift für Angewandte Mathematik und Mechanik, 2023, v. 103, n. 3, p. 1, doi. 10.1002/zamm.202100538
By:
- Poelstra, Klaas;
- Bartel, Thorsten;
- Schweizer, Ben
Publication type:
Article
Phosphate Groups in the Lipid A Moiety Determine the Effects of LPS on Hepatic Stellate Cells: A Role for LPS-Dephosphorylating Activity in Liver Fibrosis.
Published in:
Cells (2073-4409), 2020, v. 9, n. 12, p. 2708, doi. 10.3390/cells9122708
By:
- Schippers, Marlies;
- Post, Eduard;
- Eichhorn, Ilse;
- Langeland, Jitske;
- Beljaars, Leonie;
- Malo, Madhu S.;
- Hodin, Richard A.;
- Millán, José Luis;
- Popov, Yury;
- Schuppan, Detlef;
- Poelstra, Klaas
Publication type:
Article
The geometric average of curl-free fields in periodic geometries.
Published in:
Analysis (0174-4747), 2021, v. 41, n. 3, p. 179, doi. 10.1515/anly-2020-0053
By:
- Poelstra, Klaas Hendrik;
- Schweizer, Ben;
- Urban, Maik
Publication type:
Article
Induction of glomerular alkaline phosphatase after challenge with lipopolysaccharide.
Published in:
International Journal of Experimental Pathology, 2003, v. 84, n. 3, p. 135, doi. 10.1046/j.1365-2613.2003.00345.x
By:
- Kapojos, Jola J.;
- Poelstra, Klaas;
- Borghuis, Theo;
- Van Den Berg, Anke;
- Baelde, Hans J.;
- Klok, Pieter A.;
- Bakker, Winston W.
Publication type:
Article
RGD-avidin–biotin pretargeting to αvβ3 integrin enhances the proapoptotic activity of TNFα related apoptosis inducing ligand (TRAIL).
Published in:
Apoptosis, 2008, v. 13, n. 2, p. 225, doi. 10.1007/s10495-007-0166-5
By:
- Tarrus, Marc;
- Sloot, Almer;
- Temming, Kai;
- Lacombe, Marie;
- Opdam, Frank;
- Quax, Wim;
- Molema, Grietje;
- Poelstra, Klaas;
- Kok, Robbert
Publication type:
Article
Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-38678-5
By:
- Klein, Sabine;
- Frohn, Franziska;
- Magdaleno, Fernando;
- Reker-Smit, Catharina;
- Schierwagen, Robert;
- Schierwagen, Irela;
- Uschner, Frank Erhard;
- van Dijk, Fransien;
- Fürst, Dieter O.;
- Djudjaj, Sonja;
- Boor, Peter;
- Poelstra, Klaas;
- Beljaars, Leonie;
- Trebicka, Jonel
Publication type:
Article
Rational Design of RGD-Albumin Conjugates for Targeted Delivery of the VEGF-R Kinase Inhibitor PTK787 to Angiogenic Endothelium.
Published in:
ChemMedChem, 2006, v. 1, n. 11, p. 1200, doi. 10.1002/cmdc.200600201
By:
- Temming, Kai;
- Lacombe, Marie;
- Schaapveld, Roel Q. J.;
- Orfi, László;
- Kéri, Gyorgy;
- Poelstra, Klaas;
- Molema, Grietje;
- Kok, Robbert J.
Publication type:
Article
Hepatic localization of macrophage phenotypes during fibrogenesis and resolution of fibrosis in mice and humans.
Published in:
Frontiers in Immunology, 2014, v. 5, p. 1, doi. 10.3389/fimmu.2014.00430
By:
- Beljaars, Leonie;
- Schippers, Marlies;
- Reker-Smit, Catharina;
- Martinez, Fernando O.;
- Helming, Laura;
- Poelstra, Klaas;
- Melgert, Barbro N.
Publication type:
Article
Increased Liver Uptake and Reduced Hepatic Stellate Cell Activation with a Cell-Specific Conjugate of the Rho-kinase Inhibitor Y27632.
Published in:
Pharmaceutical Research, 2011, v. 28, n. 8, p. 2045, doi. 10.1007/s11095-011-0430-9
By:
- Beuge, Marike;
- Prakash, Jai;
- Lacombe, Marie;
- Post, Eduard;
- Reker-Smit, Catharina;
- Beljaars, Leonie;
- Poelstra, Klaas
Publication type:
Article
Cell-specific Delivery of a Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor to Proximal Tubular Cells for the Treatment of Renal Fibrosis.
Published in:
Pharmaceutical Research, 2008, v. 25, n. 10, p. 2427, doi. 10.1007/s11095-007-9515-x
By:
- Jai Prakash;
- Martin de Borst;
- Annemiek van Loenen-Weemaes;
- Marie Lacombe;
- Frank Opdam;
- Harry van Goor;
- Dirk Meijer;
- Frits Moolenaar;
- Klaas Poelstra
Publication type:
Article
Targeting 15d-Prostaglandin J2 to Hepatic Stellate Cells: Two Options Evaluated.
Published in:
Pharmaceutical Research, 2007, v. 24, n. 3, p. 566, doi. 10.1007/s11095-006-9175-2
By:
- Werner Hagens;
- Adriana Mattos;
- Rick Greupink;
- Alie de Jager-Krikken;
- Catharina Reker-Smit;
- AnneMiek van Loenen-Weemaes;
- Annette Gouw;
- Klaas Poelstra;
- Leonie Beljaars
Publication type:
Article
Production of hemopexin by TNF-α stimulated human mesangial cells.
Published in:
Kidney International, 2003, v. 63, n. 5, p. 1681, doi. 10.1046/j.1523-1755.2003.00907.x
By:
- Kapojos, Jola J.;
- Van Den Berg, Anke;
- Van Goor, Harry;
- Te Loo, Maroeska W.M.;
- Poelstra, Klaas;
- Borghuis, Theo;
- Bakker, Winston W.
Publication type:
Article

Found: 27

Drug Targeting and Nanomedicine: Lessons Learned from Liver Targeting and Opportunities for Drug Innovation.

Osteoprotegerin Is more than a Possible Serum Marker in Liver Fibrosis: A Study into Its Function in Human and Murine Liver.

Design of a Gene Panel to Expose the Versatile Role of Hepatic Stellate Cells in Human Liver Fibrosis.

Gliotoxin non-selectively induces apoptosis in fibrotic and normal livers.

Targeted Recombinant Fusion Proteins of IFNγ and Mimetic IFNγ with PDGFβR Bicyclic Peptide Inhibits Liver Fibrogenesis <i>In Vivo</i>.

Enhanced Effectivity of an ALK5-Inhibitor after Cell-Specific Delivery to Hepatic Stellate Cells in Mice with Liver Injury.

Anticancer Effects of 15d-Prostaglandin-J2 in Wild-Type and Doxorubicin-Resistant Ovarian Cancer Cells: Novel Actions on SIRT1 and HDAC.

Intraglomerular platelet aggregation and experimental glomerulonephritis.

Antibody-Free Detection of Protein Tyrosine Nitration in Tissue Sections.

Selective delivery of IFN-γ to renal interstitial myofibroblasts: a novel strategy for the treatment of renal fibrosis.

A role for intestinal alkaline phosphatase in the maintenance of local gut immunity.

The sphingosine 1-phosphate receptor S1P<sub>2</sub> triggers hepatic wound healing.

Necrotizing enterocolitis: a potential protective role for intestinal alkaline phosphatase as lipopolysaccharide detoxifying enzyme.

Tumor-targeted intracellular delivery of anticancer drugs through the mannose-6-phosphate/insulin-like growth factor II receptor.

Targeted elimination of activated hepatic stellate cells by an anti-epidermal growth factor-receptor single chain fragment variable antibody-tumor necrosis factor-related apoptosis-inducing ligand (scFv425-sTRAIL).

A data‐driven framework for evolutionary problems in solid mechanics.

Phosphate Groups in the Lipid A Moiety Determine the Effects of LPS on Hepatic Stellate Cells: A Role for LPS-Dephosphorylating Activity in Liver Fibrosis.

The geometric average of curl-free fields in periodic geometries.

Induction of glomerular alkaline phosphatase after challenge with lipopolysaccharide.

RGD-avidin–biotin pretargeting to α<sub>v</sub>β<sub>3</sub> integrin enhances the proapoptotic activity of TNFα related apoptosis inducing ligand (TRAIL).

Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats.

Rational Design of RGD-Albumin Conjugates for Targeted Delivery of the VEGF-R Kinase Inhibitor PTK787 to Angiogenic Endothelium.

Hepatic localization of macrophage phenotypes during fibrogenesis and resolution of fibrosis in mice and humans.

Increased Liver Uptake and Reduced Hepatic Stellate Cell Activation with a Cell-Specific Conjugate of the Rho-kinase Inhibitor Y27632.

Cell-specific Delivery of a Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor to Proximal Tubular Cells for the Treatment of Renal Fibrosis.

Targeting 15d-Prostaglandin J<sub>2</sub> to Hepatic Stellate Cells: Two Options Evaluated.

Production of hemopexin by TNF-α stimulated human mesangial cells.