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- Title
Analytical Method Development and Validation for HPLC-ECD Determination of Moxifloxacin in Marketed Formulations.
- Authors
Phani Sekhar Reddy, G.; Navyasree, K. S.; Jagadish, P. C.; Bhat, Krishnamurthy
- Abstract
An HPLC-ECD analytical method with high reproducibility and wide linearity range has been developed and validated. Moxifloxacin was separated and identified using this method with a simple mobile phase comprising Britton Robinson buffer pH 5.0 and methanol (93: 7 v/v) flowing at a rate of 0.5 mL/min through Acclaim C18 column (150 mm × 4.6 mm × 5 im) maintained at 35°C and detected at redox potential value of 1.0 V. The LOD and LOQ were found to be 2.2 and 6.6 μg/mL, respectively. The HPLC-ECD method of moxifloxacin analysis was validated as per ICH Q2R1 guidelines and applied for assay of marketed moxifloxacin formulations to establish the acceptable recovery.
- Subjects
HIGH performance liquid chromatography; MOXIFLOXACIN; METHANOL; CHROMATOGRAPHIC analysis; DRUG development
- Publication
Pharmaceutical Chemistry Journal, 2018, Vol 52, Issue 7, p674
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-018-1879-1