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- Title
Quiescencia y senescencia: enfoque traslacional al paciente oncológico y críticamente enfermo.
- Authors
Aguayo Moscoso, Santiago Xavier; Montalvo Villagómez, Santiago Xavier; Jara González, Fernando Esteban; Vélez Páez, Pablo Andrés; Velarde Montero, Carlos Gustavo; Vélez Páez, Jorge Luis
- Abstract
Quiescent cells do not divide, but retain the ability to reenter the cell cycle and resume proliferation in response to certain stimuli. The possibility of entry and exit from inactivity, doing it in an appropriate way, and remaining viable while inactive, is essential for tissue homeostasis. The other point to highlight is senescence, which is the arrest of cell proliferation, triggered by various factors, including oncogenic stress and other types of cellular stress. Senescent cells are metabolically active and have effects through a very characteristic secretory phenotype. Researchers have set out in the search for treatments aimed at different sites of the cell cycle, in cancer patients. But the studies even go further, in which they include other types of pathologies. In the critically ill patient, also at the cellular level, there are a series of studies, aimed at identifying the "senescent" characteristics that this group of patients may present.
- Publication
INSPILIP. Revista Ecuatoriana de Ciencia, Tecnología e Innovacion en Salud Pública, 2020, Vol 4, Issue 1, p1
- ISSN
2588-0551
- Publication type
Article
- DOI
10.31790/inspilip.v4i1.96.g171