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- Title
A Robust Method for Perfusable Microvascular Network Formation In Vitro.
- Authors
Wan, Zhengpeng; Zhong, Amy X.; Zhang, Shun; Pavlou, Georgios; Coughlin, Mark F.; Shelton, Sarah E.; Nguyen, Huu Tuan; Lorch, Jochen H.; Barbie, David A.; Kamm, Roger D.
- Abstract
Micropost‐based microfluidic devices are widely used for microvascular network (MVN) formation in diverse research fields. However, consistently generating perfusable MVNs of physiological morphology and dimension has proven to be challenging. Here, how initial seeding parameters determine key characteristics of MVN formation is investigated and a robust two‐step seeding strategy to generate perfusable physiological MVNs in microfluidic devices is established.
- Subjects
MICROFLUIDIC devices; MICROFLUIDICS
- Publication
Small Methods, 2022, Vol 6, Issue 6, p1
- ISSN
2366-9608
- Publication type
Article
- DOI
10.1002/smtd.202200143