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- Title
Synthesis of derivatives of pyrazolo[1,5- a]pyrimidines and imidazo[1,5- a]pyrimidines proceeding from alkyl 2-benzylidene-3-oxo-3-fluoroalkylpropionates.
- Authors
Pryadeina, M. V.; Burgart, Ya. V.; Saloutin, V. I.; Slepukhin, P. A.; Sadchikova, E. V.; Ulomskii, E. N.
- Abstract
Methods were developed of the synthesis of alkyl 2-hydroxy-2-fluoroalkyl-4-phenyl-1,2,3,4—tetrahydroimidazo-[1,5- a]pyrimidine-3-carboxylates and alkyl-5-hydroxy-2,7-diphenyl-5-fluoroalkyl-4,5,6,7-tetrahydropyrazolo[1,5- a]pyrimidine-6-carboxylates by regioselective [3+3]-cycloaddition of 5-aminoimidazole or 5-aminopyrazole to alkyl 2-benzylidene-3-oxo-3-fluoroalkylpropionates at the fluoroacylvinyl fragment.
- Subjects
PYRIMIDINES; IMIDAZOLES; ALKYLATION; CARBOXYLIC acids; CHEMICAL reactions; CARBONYL compounds
- Publication
Russian Journal of Organic Chemistry, 2009, Vol 45, Issue 2, p242
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428009020158