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- Title
Spinal epidural lipomatosis following haploidentical allogeneic bone marrow transplantation for non-Hodgkin lymphoma.
- Authors
Resnick, Igor B.; Gomori, John M.; Kiselgoff, David; Lossos, Alex; Zilberman, Irina; Miron, Svetlana; Bitan, Menachem; Or, Reuven; Slavin, Shimon; Shapira, Michael Y.
- Abstract
Resnick IB, Gomori JM, Kiselgoff D, Lossos A, Zilberman I, Miron S, Bitan M, Or R, Slavin S, Shapira MY.Spinal epidural lipomatosis following haploidentical allogeneic bone marrow transplantation for non-Hodgkin lymphoma.Clin Transplant 2004 DOI: 10.1111/j.1399-0012.2004.00290.x© Blackwell Munksgaard, 2004Spinal epidural lipomatosis, is a very rare condition, usually seen as an uncommon complication of Cushing's syndrome secondary to chronic steroid therapy leading to increased fat deposits in the epidural space.We report the first documented case of acute symptomatic spinal epidural lipomatosis in a patient with relapsed non-Hodgkin lymphoma. The patient underwent an allogeneic bone marrow transplantation (BMT) and a month of steroid treatment for acute graft vs. host disease (GvHD). He presented with a mild to moderate Cushing's syndrome and minimal obesity. He progressed rapidly to paraparesis, sensory deficit, urinary incontinence and finally respiratory arrest complicated with staphylococcal sepsis.Epidural lipomatosis, with subacute thecal sac compression, is a possible life-threatening complication of relatively short-term systemic glucocorticoid therapy for GvHD in BMT setting.
- Subjects
BONE marrow transplantation; CUSHING'S syndrome; COMPLICATIONS from organ transplantation; STEROIDS; GLUCOCORTICOIDS
- Publication
Clinical Transplantation, 2004, Vol 18, Issue 6, p762
- ISSN
0902-0063
- Publication type
Book Review
- DOI
10.1111/j.1399-0012.2004.00290.x