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- Title
Dose, efficacy and tolerability of long-term indomethacin treatment of chronic paroxysmal hemicrania and hemicrania continua.
- Authors
Pareja, JA; Caminero, AB; Franco, E; Casado, JL; Pascual, J; Sánchez del Rıo, M; Pareja, J A; Caminero, A B; Casado, J L; Sánchez del Río, M
- Abstract
Indomethacin has consistently been proven to provide complete and sustained relief of symptoms in hemicrania continua (HC) and chronic paroxysmal hemicrania (CPH), but is not devoid of side-effects. The goal of this retrospective study is to assess the dose and side-effects of prolonged indomethacin treatment of HC and CPH. Twenty-six patients with either HC or CPH were followed during an average of 3.8 years after onset of treatment with indomethacin. Relief of symptoms occurred within 3 days of treatment, with 84 +/- 32 mg/day of indomethacin. With time, 42% of patients experienced a decrease of up to 60% in the dose of indomethacin required to maintain a pain-free state. Six (23%) patients showed adverse events, mostly gastrointestinal and relieved with ranitidine. No major side-effects were observed. These results indicate that prolonged indomethacin treatment of HC or CPH has a good safety and tolerability profile with a reduction of up to 60% in the initial dose.
- Subjects
INDOMETHACIN; PAIN management; ANALGESIA; DRUG side effects; ANALGESICS; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; MIGRAINE; NONSTEROIDAL anti-inflammatory agents; RESEARCH; TIME; EVALUATION research; RETROSPECTIVE studies; THERAPEUTICS
- Publication
Cephalalgia, 2001, Vol 21, Issue 9, p906
- ISSN
0333-1024
- Publication type
journal article
- DOI
10.1046/j.1468-2982.2001.00287.x