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- Title
The 2019–2020 Dengue Fever Epidemic: Genomic Markers Indicating Severity in Dominican Republic Children.
- Authors
Simpson, Brittany N; Sang, Miguel E Mejía; Puello, Yonairy Collado; Brockmans, Elvira J Diaz; Soto, María F Díaz; Defilló, Stephanie M Rivera; Cruz, Karla M Taveras; Pérez, Javier O Santiago; Husami, Ammar; Day, Melissa E; Pilipenko, Valentina; Mena, Rafael; Mota, Cesár; Hostetter, Margaret K; Muglia, Louis J; Schlaudecker, Elizabeth; Rey, Javier Gonzalez del; Martin, Lisa J; Prada, Carlos E
- Abstract
We performed an observational cohort study to assess associations between genetic factors of dengue fever (DF) severity in children in the Dominican Republic. A total of 488 participants had serologically confirmed DF. We replicated the association between the IFIH1 gene (rs1990760) and severe DF (n = 80/488, p = 0.006) and identified novel associations needing further investigation.
- Subjects
DOMINICAN Republic; DENGUE; SCIENTIFIC observation; SEVERITY of illness index; RISK assessment; GENOMICS; GENETIC markers; DESCRIPTIVE statistics; RESEARCH funding; LONGITUDINAL method
- Publication
Journal of the Pediatric Infectious Diseases Society, 2023, Vol 12, Issue 3, p169
- ISSN
2048-7193
- Publication type
Article
- DOI
10.1093/jpids/piac136