We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Programming DNA origami patterning with non-canonical DNA-based metallization reactions.
- Authors
Sisi Jia; Jianbang Wang; Mo Xie; Jixue Sun; Huajie Liu; Yinan Zhang; Jie Chao; Jiang Li; Lihua Wang; Jianping Lin; Gothelf, Kurt V.; Chunhai Fan
- Abstract
The inherent specificity of DNA sequence hybridization has been extensively exploited to develop bioengineering applications. Nevertheless, the structural potential of DNA has been far less explored for creating non-canonical DNA-based reactions. Here we develop a DNA origami-enabled highly localized metallization reaction for intrinsic metallization patterning with 10-nm resolution. Both theoretical and experimental studies reveal that low-valence metal ions (Cu2+ and Ag+) strongly coordinate with DNA bases in protruding clustered DNA (pcDNA) prescribed on two-dimensional DNA origami, which results in effective attraction within flexible pcDNA strands for site-specific pcDNA condensation. We find that the metallization reactions occur selectively on prescribed sites while not on origami substrates. This strategy is generically applicable for free-style metal painting of alphabet letters, digits and geometric shapes on all−DNA substrates with near-unity efficiency. We have further fabricated single- and double-layer nanoscale printed circuit board (nano-PCB) mimics, shedding light on bio-inspired fabrication for nanoelectronic and nanophotonic applications.
- Publication
Nature Communications, 2019, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-019-13507-5