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Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32130-5
By:
- Lee, Annie;
- Kondapalli, Chandana;
- Virga, Daniel M.;
- Lewis Jr, Tommy L.;
- Koo, So Yeon;
- Ashok, Archana;
- Mairet-Coello, Georges;
- Herzig, Sebastien;
- Foretz, Marc;
- Viollet, Benoit;
- Shaw, Reuben;
- Sproul, Andrew;
- Polleux, Franck
Publication type:
Article
Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer's Disease-Associated Presenilin 1 Mutation.
Published in:
Frontiers in Molecular Neuroscience, 2017, p. 1, doi. 10.3389/fnmol.2017.00291
By:
- Martín-Maestro, Patricia;
- Gargini, Ricardo;
- Sproul, Andrew A.;
- García, Esther;
- Antón, Luis C.;
- Noggle, Scott;
- Arancio, Ottavio;
- Avila, Jesús;
- García-Escudero, Vega
Publication type:
Article
Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease.
Published in:
2022
By:
- Peris, Leticia;
- Parato, Julie;
- Qu, Xiaoyi;
- Soleilhac, Jean Marc;
- Lanté, Fabien;
- Kumar, Atul;
- Pero, Maria Elena;
- Martínez-Hernández, José;
- Corrao, Charlotte;
- Falivelli, Giulia;
- Payet, Floriane;
- Gory-Fauré, Sylvie;
- Bosc, Christophe;
- Ramirez, Marian Blanca;
- Sproul, Andrew;
- Brocard, Jacques;
- Cara, Benjamin Di;
- Delagrange, Philippe;
- Buisson, Alain;
- Goldberg, Yves
Publication type:
journal article
Impaired Microtubule Dynamics Are a Driver of Tau Phosphorylation.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080227
By:
- Parato, Julie;
- Qu, Xiaoyi;
- Richters, Emily;
- Sproul, Andrew;
- Bartolini, Francesca
Publication type:
Article
Loss of tubulin tyrosine ligase, a novel feature of sporadic and familial AD, is an enhancer of tau phosphorylation.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.075861
By:
- Parato, Julie;
- Qu, Xiaoyi;
- Sproul, Andrew;
- Pero, Maria Elena;
- Bartolini, Francesca
Publication type:
Article
Loss of tubulin tyrosine ligase, a novel feature of sporadic and familial AD, is an enhancer of tau phosphorylation.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.075861
By:
- Parato, Julie;
- Qu, Xiaoyi;
- Sproul, Andrew;
- Pero, Maria Elena;
- Bartolini, Francesca
Publication type:
Article
The pathogenic role of tubulin tyrosine ligase and D2 tubulin in Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.056351
By:
- Parato, Julie;
- Kumar, Atul;
- Pero, Maria Elena;
- Qu, Xiaoyi;
- Ramírez, Marian Blanca;
- Sproul, Andrew;
- Bartolini, Francesca
Publication type:
Article
The Alzheimer's disease‐associated C99 fragment of APP regulates cellular cholesterol trafficking.
Published in:
EMBO Journal, 2020, v. 39, n. 20, p. 1, doi. 10.15252/embj.2019103791
By:
- Montesinos, Jorge;
- Pera, Marta;
- Larrea, Delfina;
- Guardia‐Laguarta, Cristina;
- Agrawal, Rishi R;
- Velasco, Kevin R;
- Yun, Taekyung D;
- Stavrovskaya, Irina G;
- Xu, Yimeng;
- Koo, So Yeon;
- Snead, Amanda M;
- Sproul, Andrew A;
- Area‐Gomez, Estela
Publication type:
Article
A NOVEL HUMAN IPSC-BASED MODEL OF ALZHEIMER'S DISEASE GENERATED BY KNOCK-IN OF EARLY-ONSET AD MUTATIONS DISPLAYS DISEASE-RELEVANT, ZYGOSITY-DEPENDENT PHENOTYPES.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P267, doi. 10.1016/j.jalz.2016.06.484
By:
- Kwart, Dylan;
- Paquet, Dominik;
- Chen, Antonia;
- Sproul, Andrew;
- Jacob, Samson;
- Teo, Shaun;
- Olsen, Kimberly Moore;
- Gregg, Andrew;
- Noggle, Scott;
- Tessier-Lavigne, Marc
Publication type:
Article
EFFICIENT INTRODUCTION OF DISEASE-RELATED MUTATIONS INTO HUMAN IPSCS USING CRISPR/CAS9 TO MODEL ALZHEIMER’S DISEASE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P1142, doi. 10.1016/j.jalz.2016.07.026
By:
- Kwart, Dylan;
- Paquet, Dominik;
- Chen, Antonia;
- Sproul, Andrew;
- Jacob, Samson;
- Teo, Shaun;
- Olsen, Kimberly Moore;
- Gregg, Andrew;
- Noggle, Scott;
- Tessier-Lavigne, Marc
Publication type:
Article
CHARACTERIZATION OF BASAL FOREBRAIN CHOLINERGIC NEURONS FROM INDUCED PLURIPOTENT STEM CELLS HARBORING FAMILIAL ALZHEIMER’S MUTATION PSEN2N141I.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P1139, doi. 10.1016/j.jalz.2016.07.020
By:
- Ortiz-Virumbrales, Maitane;
- Moreno, Cesar;
- Sproul, Andrew;
- Jacob, Samson;
- Zimmer, Matthew;
- Kruglikov, Ilya;
- Paull, Daniel;
- Marazuela, Paula;
- Ehrlich, Michelle E.;
- Tanzi, Rudolph;
- Schadt, Eric;
- Noggle, Scott;
- Gandy, Samuel
Publication type:
Article
Development of an induced pluripotent stem cell (iPSC) Alzheimer's disease model using PSEN1 mutant fibroblasts
Published in:
2012
By:
- Sproul, Andrew A.;
- Jacob, Samson;
- Nestor, Michael W.;
- Keilani, Serene;
- Jean, Ying;
- Kahler, David J.;
- Santa-Maria, Ismael;
- Steele, John;
- Crary, John F.;
- Troy, Carol M.;
- Gandy, Sam;
- Noggle, Scott A.
Publication type:
Abstract
Development of an induced pluripotent stem cell (iPSC) Alzheimer's disease model using PSEN1 mutant fibroblasts
Published in:
2012
By:
- Sproul, Andrew;
- Jacob, Samson;
- Nestor, Michael;
- Keilani, Serene;
- Jean, Ying;
- Kahler, Dave;
- Santa-Maria, Ismael;
- Steele, John;
- Crary, John;
- Troy, Carol;
- Gandy, Sam;
- Noggle, Scott
Publication type:
Abstract
The Sixth Annual Translational Stem Cell Research Conference of the New York Stem Cell Foundation.
Published in:
Annals of the New York Academy of Sciences, 2012, v. 1255, n. 1, p. 16, doi. 10.1111/j.1749-6632.2012.06481.x
By:
- Marshall, Caroline;
- Hua, Haiqing;
- Shang, Linshan;
- Ding, Bi‐Sen;
- Zito, Giovanni;
- de Peppo, Giuseppe Maria;
- Wang, George Kai;
- Douvaras, Panagiotis;
- Sproul, Andrew A.;
- Paull, Daniel;
- Fossati, Valentina;
- Nestor, Michael W.;
- McKeon, David;
- Smith, Kristin A.;
- Solomon, Susan L.
Publication type:
Article
The New York Stem Cell Foundation: Fifth Annual Translational Stem Cell Research Conference.
Published in:
Annals of the New York Academy of Sciences, 2011, v. 1226, n. 1, p. 1, doi. 10.1111/j.1749-6632.2011.06038.x
By:
- Marshall, Caroline;
- Kai Wang, George;
- Cimetta, Elisa;
- Talchai, Chutima;
- Egli, Dieter;
- Shim, Jae‐won;
- Martin, Ian;
- Ahmad, Faizzan;
- Sproul, Andrew;
- Chen, Ting;
- Fossati, Valentina;
- McKeon, David;
- Smith, Kristin;
- Solomon, Susan L.
Publication type:
Article
A Time Course Analysis of the Electrophysiological Properties of Neurons Differentiated from Human Induced Pluripotent Stem Cells (iPSCs).
Published in:
PLoS ONE, 2014, v. 9, n. 7, p. 1, doi. 10.1371/journal.pone.0103418
By:
- Prè, Deborah;
- Nestor, Michael W.;
- Sproul, Andrew A.;
- Jacob, Samson;
- Koppensteiner, Peter;
- Chinchalongporn, Vorapin;
- Zimmer, Matthew;
- Yamamoto, Ai;
- Noggle, Scott A.;
- Arancio, Ottavio
Publication type:
Article
Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors.
Published in:
PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0084547
By:
- Sproul, Andrew A.;
- Jacob, Samson;
- Pre, Deborah;
- Kim, Soong Ho;
- Nestor, Michael W.;
- Navarro-Sobrino, Miriam;
- Santa-Maria, Ismael;
- Zimmer, Matthew;
- Aubry, Soline;
- Steele, John W.;
- Kahler, David J.;
- Dranovsky, Alex;
- Arancio, Ottavio;
- Crary, John F.;
- Gandy, Sam;
- Noggle, Scott A.
Publication type:
Article
Improved Methods for Reprogramming Human Dermal Fibroblasts Using Fluorescence Activated Cell Sorting.
Published in:
PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0059867
By:
- Kahler, David J.;
- Ahmad, Faizzan S.;
- Ritz, Anita;
- Hua, Haiqing;
- Moroziewicz, Dorota N.;
- Sproul, Andrew A.;
- Dusenberry, Carmen R.;
- Shang, Linshan;
- Paull, Daniel;
- Zimmer, Matthew;
- Weiss, Keren A.;
- Egli, Dieter;
- Noggle, Scott A.
Publication type:
Article
CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2N141I neurons.
Published in:
Acta Neuropathologica Communications, 2017, v. 5, p. 1, doi. 10.1186/s40478-017-0475-z
By:
- Ortiz-Virumbrales, Maitane;
- Moreno, Cesar L.;
- Kruglikov, Ilya;
- Marazuela, Paula;
- Sproul, Andrew;
- Jacob, Samson;
- Zimmer, Matthew;
- Paull, Daniel;
- Bin Zhang;
- Schadt, Eric E.;
- Ehrlich, Michelle E.;
- Tanzi, Rudolph E.;
- Arancio, Ottavio;
- Noggle, Scott;
- Gandy, Sam
Publication type:
Article
CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-018-07971-8
By:
- Sun, Jichao;
- Carlson-Stevermer, Jared;
- Das, Utpal;
- Shen, Minjie;
- Delenclos, Marion;
- Snead, Amanda M.;
- Koo, So Yeon;
- Wang, Lina;
- Qiao, Dianhua;
- Loi, Jonathan;
- Petersen, Andrew J.;
- Stockton, Michael;
- Bhattacharyya, Anita;
- Jones, Mathew V.;
- Zhao, Xinyu;
- McLean, Pamela J.;
- Sproul, Andrew A.;
- Saha, Krishanu;
- Roy, Subhojit
Publication type:
Article
Cbl negatively regulates JNK activation and cell death.
Published in:
Cell Research, 2009, v. 19, n. 8, p. 950, doi. 10.1038/cr.2009.74
By:
- Sproul, Andrew A.;
- Zhiheng Xu;
- Wilhelm, Michael;
- Gire, Stephen;
- Greene, Lloyd A.
Publication type:
Article
Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics.
Published in:
Cell Death & Disease, 2022, v. 13, n. 11, p. 1, doi. 10.1038/s41419-022-05396-2
By:
- Bosc, Elodie;
- Anastasie, Julie;
- Soualmia, Feryel;
- Coric, Pascale;
- Kim, Ju Youn;
- Wang, Lily Q.;
- Lacin, Gullen;
- Zhao, Kaitao;
- Patel, Ronak;
- Duplus, Eric;
- Tixador, Philippe;
- Sproul, Andrew A.;
- Brugg, Bernard;
- Reboud-Ravaux, Michelle;
- Troy, Carol M.;
- Shelanski, Michael L.;
- Bouaziz, Serge;
- Karin, Michael;
- El Amri, Chahrazade;
- Jacotot, Etienne D.
Publication type:
Article
Xenografted human iPSC-derived neurons with the familial Alzheimer's disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator.
Published in:
Acta Neuropathologica, 2024, v. 147, n. 1, p. 1, doi. 10.1007/s00401-024-02755-5
By:
- Qu, Wenhui;
- Lam, Matti;
- McInvale, Julie J.;
- Mares, Jason A.;
- Kwon, Sam;
- Humala, Nelson;
- Mahajan, Aayushi;
- Nguyen, Trang;
- Jakubiak, Kelly A.;
- Mun, Jeong-Yeon;
- Tedesco, Thomas G.;
- Al-Dalahmah, Osama;
- Hussaini, Syed A.;
- Sproul, Andrew A.;
- Siegelin, Markus D.;
- De Jager, Philip L.;
- Canoll, Peter;
- Menon, Vilas;
- Hargus, Gunnar
Publication type:
Article
RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation.
Published in:
Acta Neuropathologica, 2023, v. 145, n. 1, p. 29, doi. 10.1007/s00401-022-02511-7
By:
- Kim, Yoon A.;
- Siddiqui, Tohid;
- Blaze, Jennifer;
- Cosacak, Mehmet Ilyas;
- Winters, Tristan;
- Kumar, Atul;
- Tein, Ellen;
- Sproul, Andrew A.;
- Teich, Andrew F.;
- Bartolini, Francesca;
- Akbarian, Schahram;
- Kizil, Caghan;
- Hargus, Gunnar;
- Santa-Maria, Ismael
Publication type:
Article
Efficient Derivation of Excitatory and Inhibitory Neurons from Human Pluripotent Stem Cells Stably Expressing Direct Reprogramming Factors.
Published in:
Current Protocols, 2021, v. 1, n. 6, p. 1, doi. 10.1002/cpz1.141
By:
- Song, Saera;
- Ashok, Archana;
- Williams, Damian;
- Kaufman, Maria;
- Duff, Karen;
- Sproul, Andrew
Publication type:
Article
Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer's Disease iPSC-Derived Neural Stem Cells.
Published in:
Molecular Neurobiology, 2019, v. 56, n. 12, p. 8220, doi. 10.1007/s12035-019-01665-y
By:
- Martín-Maestro, Patricia;
- Sproul, Andrew;
- Martinez, Hector;
- Paquet, Dominik;
- Gerges, Meri;
- Noggle, Scott;
- Starkov, Anatoly A.
Publication type:
Article

Found: 26

Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy.

Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer's Disease-Associated Presenilin 1 Mutation.

Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease.

Impaired Microtubule Dynamics Are a Driver of Tau Phosphorylation.

Loss of tubulin tyrosine ligase, a novel feature of sporadic and familial AD, is an enhancer of tau phosphorylation.

Loss of tubulin tyrosine ligase, a novel feature of sporadic and familial AD, is an enhancer of tau phosphorylation.

The pathogenic role of tubulin tyrosine ligase and D2 tubulin in Alzheimer's disease.

The Alzheimer's disease‐associated C99 fragment of APP regulates cellular cholesterol trafficking.

A NOVEL HUMAN IPSC-BASED MODEL OF ALZHEIMER'S DISEASE GENERATED BY KNOCK-IN OF EARLY-ONSET AD MUTATIONS DISPLAYS DISEASE-RELEVANT, ZYGOSITY-DEPENDENT PHENOTYPES.

EFFICIENT INTRODUCTION OF DISEASE-RELATED MUTATIONS INTO HUMAN IPSCS USING CRISPR/CAS9 TO MODEL ALZHEIMER’S DISEASE.

CHARACTERIZATION OF BASAL FOREBRAIN CHOLINERGIC NEURONS FROM INDUCED PLURIPOTENT STEM CELLS HARBORING FAMILIAL ALZHEIMER’S MUTATION PSEN2N141I.

Development of an induced pluripotent stem cell (iPSC) Alzheimer's disease model using PSEN1 mutant fibroblasts

Development of an induced pluripotent stem cell (iPSC) Alzheimer's disease model using PSEN1 mutant fibroblasts

The Sixth Annual Translational Stem Cell Research Conference of the New York Stem Cell Foundation.

The New York Stem Cell Foundation: Fifth Annual Translational Stem Cell Research Conference.

A Time Course Analysis of the Electrophysiological Properties of Neurons Differentiated from Human Induced Pluripotent Stem Cells (iPSCs).

Characterization and Molecular Profiling of <i>PSEN1</i> Familial Alzheimer's Disease iPSC-Derived Neural Progenitors.

Improved Methods for Reprogramming Human Dermal Fibroblasts Using Fluorescence Activated Cell Sorting.

CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2<sup>N141I</sup> neurons.

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage.

Cbl negatively regulates JNK activation and cell death.

Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics.

Xenografted human iPSC-derived neurons with the familial Alzheimer's disease APP<sup>V717I</sup> mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator.

RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation.

Efficient Derivation of Excitatory and Inhibitory Neurons from Human Pluripotent Stem Cells Stably Expressing Direct Reprogramming Factors.

Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer's Disease iPSC-Derived Neural Stem Cells.